node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRA2 | ANKRD46 | ENSP00000296785 | ENSP00000429015 | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity). | Ankyrin repeat domain 46. | 0.515 |
ANKRD46 | ANKRA2 | ENSP00000429015 | ENSP00000296785 | Ankyrin repeat domain 46. | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity). | 0.515 |
ANKRD46 | ASZ1 | ENSP00000429015 | ENSP00000284629 | Ankyrin repeat domain 46. | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the p [...] | 0.500 |
ANKRD46 | ATRN | ENSP00000429015 | ENSP00000262919 | Ankyrin repeat domain 46. | Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). | 0.716 |
ANKRD46 | CUL1 | ENSP00000429015 | ENSP00000326804 | Ankyrin repeat domain 46. | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1- F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] | 0.494 |
ANKRD46 | MEGF8 | ENSP00000429015 | ENSP00000251268 | Ankyrin repeat domain 46. | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. | 0.543 |
ANKRD46 | MGRN1 | ENSP00000429015 | ENSP00000262370 | Ankyrin repeat domain 46. | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). | 0.784 |
ANKRD46 | POTEH | ENSP00000429015 | ENSP00000340610 | Ankyrin repeat domain 46. | POTE ankyrin domain family member H. | 0.495 |
ANKRD46 | POTEM | ENSP00000429015 | ENSP00000448062 | Ankyrin repeat domain 46. | POTE ankyrin domain family member M; Belongs to the POTE family. | 0.499 |
ANKRD46 | PSG1 | ENSP00000429015 | ENSP00000308970 | Ankyrin repeat domain 46. | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family. | 0.625 |
ANKRD46 | PSG3 | ENSP00000429015 | ENSP00000332215 | Ankyrin repeat domain 46. | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | 0.792 |
ASZ1 | ANKRD46 | ENSP00000284629 | ENSP00000429015 | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the p [...] | Ankyrin repeat domain 46. | 0.500 |
ASZ1 | POTEH | ENSP00000284629 | ENSP00000340610 | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the p [...] | POTE ankyrin domain family member H. | 0.589 |
ASZ1 | POTEM | ENSP00000284629 | ENSP00000448062 | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the p [...] | POTE ankyrin domain family member M; Belongs to the POTE family. | 0.533 |
ATRN | ANKRD46 | ENSP00000262919 | ENSP00000429015 | Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). | Ankyrin repeat domain 46. | 0.716 |
ATRN | MGRN1 | ENSP00000262919 | ENSP00000262370 | Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). | 0.992 |
CUL1 | ANKRD46 | ENSP00000326804 | ENSP00000429015 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1- F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] | Ankyrin repeat domain 46. | 0.494 |
MEGF8 | ANKRD46 | ENSP00000251268 | ENSP00000429015 | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. | Ankyrin repeat domain 46. | 0.543 |
MEGF8 | MGRN1 | ENSP00000251268 | ENSP00000262370 | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). | 0.975 |
MEGF8 | PSG1 | ENSP00000251268 | ENSP00000308970 | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family. | 0.693 |