STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ETV3LETS translocation variant 3-like protein; Transcriptional regulator; Belongs to the ETS family. (361 aa)    
Predicted Functional Partners:
LRRC71
Leucine-rich repeat-containing protein 71; Leucine rich repeat containing 71.
      
 0.595
PABPC1L2B
poly(A) binding protein cytoplasmic 1 like 2B.
      
 0.453
WDR86
WD repeat domain 86.
    
 
 0.450
C17orf107
Uncharacterized protein C17orf107; Chromosome 17 open reading frame 107.
      
 0.447
ARHGEF11
Rho guanine nucleotide exchange factor 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
 
    
 0.421
LRRIQ4
Leucine rich repeats and IQ motif containing 4.
    
 
 0.420
UBXN10
UBX domain-containing protein 10; VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT- B) in cilia. UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 ; Belongs to the UBXN10 family.
   
  
 0.411
PEAR1
Platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
      
 0.404
SSX7
Protein SSX7; Could act as a modulator of transcription; Belongs to the SSX family.
      
 0.400
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.