node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHD4 | ZFHX4 | ENSP00000440542 | ENSP00000498627 | Chromodomain-helicase-DNA-binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Belongs to the SNF2/RAD54 helicase family. | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. | 0.862 |
CSMD3 | FAT3 | ENSP00000297405 | ENSP00000432586 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | 0.678 |
CSMD3 | FAT4 | ENSP00000297405 | ENSP00000377862 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). | 0.574 |
CSMD3 | LRP1B | ENSP00000297405 | ENSP00000374135 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. | 0.779 |
CSMD3 | MUC16 | ENSP00000297405 | ENSP00000381008 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. | 0.721 |
CSMD3 | RYR2 | ENSP00000297405 | ENSP00000355533 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. Belongs to the ryanodine rec [...] | 0.613 |
CSMD3 | SYNE1 | ENSP00000297405 | ENSP00000356224 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus- centrosome attachment and nuclear migrati [...] | 0.674 |
CSMD3 | TTN | ENSP00000297405 | ENSP00000467141 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase; Belongs to the protein kinase su [...] | 0.724 |
CSMD3 | USH2A | ENSP00000297405 | ENSP00000305941 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Usherin; Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. | 0.658 |
CSMD3 | ZFHX4 | ENSP00000297405 | ENSP00000498627 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. | 0.664 |
FAT3 | CSMD3 | ENSP00000432586 | ENSP00000297405 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | CUB and sushi domain-containing protein 3; Involved in dendrite development. | 0.678 |
FAT3 | FAT4 | ENSP00000432586 | ENSP00000377862 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). | 0.414 |
FAT3 | MUC16 | ENSP00000432586 | ENSP00000381008 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. | 0.547 |
FAT3 | RYR2 | ENSP00000432586 | ENSP00000355533 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. Belongs to the ryanodine rec [...] | 0.460 |
FAT3 | SYNE1 | ENSP00000432586 | ENSP00000356224 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus- centrosome attachment and nuclear migrati [...] | 0.474 |
FAT3 | TTN | ENSP00000432586 | ENSP00000467141 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase; Belongs to the protein kinase su [...] | 0.453 |
FAT3 | USH2A | ENSP00000432586 | ENSP00000305941 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Usherin; Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. | 0.488 |
FAT3 | ZFHX4 | ENSP00000432586 | ENSP00000498627 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. | 0.573 |
FAT4 | CSMD3 | ENSP00000377862 | ENSP00000297405 | Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). | CUB and sushi domain-containing protein 3; Involved in dendrite development. | 0.574 |
FAT4 | FAT3 | ENSP00000377862 | ENSP00000432586 | Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | 0.414 |