E5RI56_HUMAN protein (human) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC34	E5RI56_HUMAN	ENSP00000215574	ENSP00000430774	Ubiquitin-conjugating enzyme E2 R1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3- primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Coope [...]	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.592
CDC34	UBE2R2	ENSP00000215574	ENSP00000263228	Ubiquitin-conjugating enzyme E2 R1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3- primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Coope [...]	Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.	0.991
COPS5	E5RI56_HUMAN	ENSP00000350512	ENSP00000430774	COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD [...]	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.809
COPS5	SUGT1	ENSP00000350512	ENSP00000367208	COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD [...]	Protein SGT1 homolog; May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.	0.602
DMXL1	DMXL2	ENSP00000439479	ENSP00000441858	DmX-like protein 1; Dmx like 1.	DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).	0.985
DMXL1	E5RI56_HUMAN	ENSP00000439479	ENSP00000430774	DmX-like protein 1; Dmx like 1.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.575
DMXL1	ROGDI	ENSP00000439479	ENSP00000322832	DmX-like protein 1; Dmx like 1.	Protein rogdi homolog; Rogdi atypical leucine zipper.	0.999
DMXL2	DMXL1	ENSP00000441858	ENSP00000439479	DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).	DmX-like protein 1; Dmx like 1.	0.985
DMXL2	E5RI56_HUMAN	ENSP00000441858	ENSP00000430774	DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.575
DMXL2	ROGDI	ENSP00000441858	ENSP00000322832	DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).	Protein rogdi homolog; Rogdi atypical leucine zipper.	0.990
E5RI56_HUMAN	CDC34	ENSP00000430774	ENSP00000215574	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Ubiquitin-conjugating enzyme E2 R1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3- primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Coope [...]	0.592
E5RI56_HUMAN	COPS5	ENSP00000430774	ENSP00000350512	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD [...]	0.809
E5RI56_HUMAN	DMXL1	ENSP00000430774	ENSP00000439479	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	DmX-like protein 1; Dmx like 1.	0.575
E5RI56_HUMAN	DMXL2	ENSP00000430774	ENSP00000441858	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).	0.575
E5RI56_HUMAN	EXOC5	ENSP00000430774	ENSP00000484855	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Exocyst complex component 5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	0.774
E5RI56_HUMAN	MPPE1	ENSP00000430774	ENSP00000465894	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI- anchor proteins; Belongs to the metallophosphoesterase superfamily. MPPE1 family.	0.610
E5RI56_HUMAN	PPP1R42	ENSP00000430774	ENSP00000315035	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Protein phosphatase 1 regulatory subunit 42; Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.	0.607
E5RI56_HUMAN	ROGDI	ENSP00000430774	ENSP00000322832	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Protein rogdi homolog; Rogdi atypical leucine zipper.	0.772
E5RI56_HUMAN	SUGT1	ENSP00000430774	ENSP00000367208	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Protein SGT1 homolog; May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.	0.604
E5RI56_HUMAN	UBE2R2	ENSP00000430774	ENSP00000263228	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.	0.592