SMIM23 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL17A1	SMIM23	ENSP00000497653	ENSP00000430818	120 kDa linear IgA disease antigen; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.	Small integral membrane protein 23.	0.540
CTBS	SMIM23	ENSP00000359664	ENSP00000430818	Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Belongs to the glycosyl hydrolase 18 family.	Small integral membrane protein 23.	0.538
DCHS2	SMIM23	ENSP00000349768	ENSP00000430818	Protocadherin-23; Calcium-dependent cell-adhesion protein.	Small integral membrane protein 23.	0.574
DHX35	SMIM23	ENSP00000252011	ENSP00000430818	Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily.	Small integral membrane protein 23.	0.441
IQCJ-SCHIP1	SCHIP1	ENSP00000420182	ENSP00000404860	IQCJ-SCHIP1 readthrough transcript protein; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments. May also play a role in axon outgrowth and guidance (By similarity).	Schwannomin interacting protein 1.	0.978
IQCJ-SCHIP1	SMIM23	ENSP00000420182	ENSP00000430818	IQCJ-SCHIP1 readthrough transcript protein; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments. May also play a role in axon outgrowth and guidance (By similarity).	Small integral membrane protein 23.	0.445
LCE6A	SMIM23	ENSP00000411070	ENSP00000430818	Late cornified envelope protein 6A; Precursors of the cornified envelope of the stratum corneum. Belongs to the LCE family.	Small integral membrane protein 23.	0.484
PAX3	SMIM23	ENSP00000375921	ENSP00000430818	Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 ; Belongs to the paired homeobox family.	Small integral membrane protein 23.	0.466
PRDM16	SMIM23	ENSP00000270722	ENSP00000430818	Histone-lysine N-methyltransferase PRDM16; Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic [...]	Small integral membrane protein 23.	0.470
SCHIP1	IQCJ-SCHIP1	ENSP00000404860	ENSP00000420182	Schwannomin interacting protein 1.	IQCJ-SCHIP1 readthrough transcript protein; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments. May also play a role in axon outgrowth and guidance (By similarity).	0.978
SCHIP1	SMIM23	ENSP00000404860	ENSP00000430818	Schwannomin interacting protein 1.	Small integral membrane protein 23.	0.455
SMIM23	COL17A1	ENSP00000430818	ENSP00000497653	Small integral membrane protein 23.	120 kDa linear IgA disease antigen; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.	0.540
SMIM23	CTBS	ENSP00000430818	ENSP00000359664	Small integral membrane protein 23.	Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Belongs to the glycosyl hydrolase 18 family.	0.538
SMIM23	DCHS2	ENSP00000430818	ENSP00000349768	Small integral membrane protein 23.	Protocadherin-23; Calcium-dependent cell-adhesion protein.	0.574
SMIM23	DHX35	ENSP00000430818	ENSP00000252011	Small integral membrane protein 23.	Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily.	0.441
SMIM23	IQCJ-SCHIP1	ENSP00000430818	ENSP00000420182	Small integral membrane protein 23.	IQCJ-SCHIP1 readthrough transcript protein; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments. May also play a role in axon outgrowth and guidance (By similarity).	0.445
SMIM23	LCE6A	ENSP00000430818	ENSP00000411070	Small integral membrane protein 23.	Late cornified envelope protein 6A; Precursors of the cornified envelope of the stratum corneum. Belongs to the LCE family.	0.484
SMIM23	PAX3	ENSP00000430818	ENSP00000375921	Small integral membrane protein 23.	Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 ; Belongs to the paired homeobox family.	0.466
SMIM23	PRDM16	ENSP00000430818	ENSP00000270722	Small integral membrane protein 23.	Histone-lysine N-methyltransferase PRDM16; Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic [...]	0.470
SMIM23	SCHIP1	ENSP00000430818	ENSP00000404860	Small integral membrane protein 23.	Schwannomin interacting protein 1.	0.455