C11orf98 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C11orf98	C19orf53	ENSP00000432523	ENSP00000465432	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	0.935
C11orf98	GNL2	ENSP00000432523	ENSP00000362153	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.	0.848
C11orf98	GTPBP4	ENSP00000432523	ENSP00000354040	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.862
C11orf98	LBHD1	ENSP00000432523	ENSP00000436848	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	LBH domain containing 1.	0.979
C11orf98	LLPH	ENSP00000432523	ENSP00000266604	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.	0.830
C11orf98	MRTO4	ENSP00000432523	ENSP00000364320	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.834
C11orf98	NOP53	ENSP00000432523	ENSP00000246802	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...]	0.818
C11orf98	RPL29	ENSP00000432523	ENSP00000294189	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	60S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family.	0.832
C11orf98	RPL36	ENSP00000432523	ENSP00000464342	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	60S ribosomal protein L36; Component of the large ribosomal subunit.	0.834
C11orf98	SDAD1	ENSP00000432523	ENSP00000348596	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.	0.852
C19orf53	C11orf98	ENSP00000465432	ENSP00000432523	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	0.935
C19orf53	GNL2	ENSP00000465432	ENSP00000362153	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.	0.807
C19orf53	GTPBP4	ENSP00000465432	ENSP00000354040	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.807
C19orf53	LLPH	ENSP00000465432	ENSP00000266604	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.	0.814
C19orf53	MRTO4	ENSP00000465432	ENSP00000364320	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.808
C19orf53	NOP53	ENSP00000465432	ENSP00000246802	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...]	0.831
C19orf53	RPL29	ENSP00000465432	ENSP00000294189	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	60S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family.	0.846
C19orf53	RPL36	ENSP00000465432	ENSP00000464342	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	60S ribosomal protein L36; Component of the large ribosomal subunit.	0.859
C19orf53	SDAD1	ENSP00000465432	ENSP00000348596	Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.	0.824
GNL2	C11orf98	ENSP00000362153	ENSP00000432523	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.	Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.	0.848