node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSMD3 | FAT3 | ENSP00000297405 | ENSP00000432586 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | 0.678 |
CSMD3 | GABRA6 | ENSP00000297405 | ENSP00000274545 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | 0.593 |
CSMD3 | ZFHX4 | ENSP00000297405 | ENSP00000498627 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. | 0.664 |
CTNNB1 | FAT3 | ENSP00000495360 | ENSP00000432586 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | 0.574 |
CTNNB1 | VASP | ENSP00000495360 | ENSP00000245932 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...] | 0.700 |
FAT3 | CSMD3 | ENSP00000432586 | ENSP00000297405 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | CUB and sushi domain-containing protein 3; Involved in dendrite development. | 0.678 |
FAT3 | CTNNB1 | ENSP00000432586 | ENSP00000495360 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.574 |
FAT3 | FJX1 | ENSP00000432586 | ENSP00000400223 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching. Belongs to the FJX1/FJ family. | 0.822 |
FAT3 | GABRA6 | ENSP00000432586 | ENSP00000274545 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | 0.594 |
FAT3 | LAMA1 | ENSP00000432586 | ENSP00000374309 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Laminin subunit alpha-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | 0.601 |
FAT3 | LAMC1 | ENSP00000432586 | ENSP00000258341 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | 0.653 |
FAT3 | MTNR1A | ENSP00000432586 | ENSP00000302811 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Melatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family. | 0.804 |
FAT3 | MTNR1B | ENSP00000432586 | ENSP00000257068 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Melatonin receptor type 1B; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. | 0.831 |
FAT3 | VASP | ENSP00000432586 | ENSP00000245932 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...] | 0.549 |
FAT3 | ZFHX4 | ENSP00000432586 | ENSP00000498627 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. | 0.573 |
FJX1 | FAT3 | ENSP00000400223 | ENSP00000432586 | Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching. Belongs to the FJX1/FJ family. | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | 0.822 |
GABRA6 | CSMD3 | ENSP00000274545 | ENSP00000297405 | Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | CUB and sushi domain-containing protein 3; Involved in dendrite development. | 0.593 |
GABRA6 | FAT3 | ENSP00000274545 | ENSP00000432586 | Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | 0.594 |
LAMA1 | FAT3 | ENSP00000374309 | ENSP00000432586 | Laminin subunit alpha-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | 0.601 |
LAMA1 | LAMC1 | ENSP00000374309 | ENSP00000258341 | Laminin subunit alpha-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | 0.944 |