| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DEDD2 | MACO1 | ENSP00000471512 | ENSP00000363463 | DNA-binding death effector domain-containing protein 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.440 |
| DEDD2 | YPEL4 | ENSP00000471512 | ENSP00000432648 | DNA-binding death effector domain-containing protein 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.454 |
| MACO1 | DEDD2 | ENSP00000363463 | ENSP00000471512 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | DNA-binding death effector domain-containing protein 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. | 0.440 |
| MACO1 | RANBP10 | ENSP00000363463 | ENSP00000316589 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN G [...] | 0.420 |
| MACO1 | YPEL4 | ENSP00000363463 | ENSP00000432648 | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.506 |
| OR4K15 | YPEL4 | ENSP00000304077 | ENSP00000432648 | Olfactory receptor 4K15; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.424 |
| OR6K2 | YPEL4 | ENSP00000352626 | ENSP00000432648 | Olfactory receptor 6K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.457 |
| OR9G4 | YPEL4 | ENSP00000307515 | ENSP00000432648 | Olfactory receptor 9G4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.441 |
| PPP1R10 | YPEL4 | ENSP00000365694 | ENSP00000432648 | Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) [...] | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.427 |
| RANBP10 | MACO1 | ENSP00000316589 | ENSP00000363463 | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN G [...] | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.420 |
| RANBP10 | WDR26 | ENSP00000316589 | ENSP00000498603 | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN G [...] | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubi [...] | 0.995 |
| RANBP10 | YPEL4 | ENSP00000316589 | ENSP00000432648 | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN G [...] | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.525 |
| TMCC2 | TSPO2 | ENSP00000350718 | ENSP00000362255 | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. | Translocator protein 2; Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation. | 0.585 |
| TMCC2 | YPEL4 | ENSP00000350718 | ENSP00000432648 | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.465 |
| TSPO2 | TMCC2 | ENSP00000362255 | ENSP00000350718 | Translocator protein 2; Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation. | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. | 0.585 |
| TSPO2 | YPEL4 | ENSP00000362255 | ENSP00000432648 | Translocator protein 2; Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation. | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.423 |
| WDR26 | RANBP10 | ENSP00000498603 | ENSP00000316589 | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubi [...] | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN G [...] | 0.995 |
| WDR26 | YPEL4 | ENSP00000498603 | ENSP00000432648 | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubi [...] | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | 0.469 |
| YPEL4 | DEDD2 | ENSP00000432648 | ENSP00000471512 | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | DNA-binding death effector domain-containing protein 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. | 0.454 |
| YPEL4 | MACO1 | ENSP00000432648 | ENSP00000363463 | Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. | Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. | 0.506 |
STRING v12.5 is now available!
