node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR8 | FAM118B | ENSP00000336842 | ENSP00000433343 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | 0.484 |
C11orf95 | FAM118B | ENSP00000482180 | ENSP00000433343 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | 0.824 |
C11orf95 | MAMLD1 | ENSP00000482180 | ENSP00000414517 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family. | 0.747 |
C11orf95 | RELA | ENSP00000482180 | ENSP00000384273 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kap [...] | 0.717 |
C11orf95 | YAP1 | ENSP00000482180 | ENSP00000478927 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] | 0.618 |
FAM118B | ACTR8 | ENSP00000433343 | ENSP00000336842 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. | 0.484 |
FAM118B | C11orf95 | ENSP00000433343 | ENSP00000482180 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | 0.824 |
FAM118B | INTS4 | ENSP00000433343 | ENSP00000434466 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.461 |
FAM118B | MAMLD1 | ENSP00000433343 | ENSP00000414517 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family. | 0.822 |
FAM118B | MED7 | ENSP00000433343 | ENSP00000286317 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.451 |
FAM118B | MFAP1 | ENSP00000433343 | ENSP00000267812 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Microfibrillar-associated protein 1; Involved in pre-mRNA splicing as a component of the spliceosome; Belongs to the MFAP1 family. | 0.463 |
FAM118B | NUTM1 | ENSP00000433343 | ENSP00000444896 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | NUT family member 1; Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. | 0.472 |
FAM118B | RELA | ENSP00000433343 | ENSP00000384273 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kap [...] | 0.461 |
FAM118B | SLC25A17 | ENSP00000433343 | ENSP00000390722 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Peroxisomal membrane protein PMP34; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'- phosphate and bathophenanthroline in vitro. Belongs to the mitochondrial carrie [...] | 0.455 |
FAM118B | YAP1 | ENSP00000433343 | ENSP00000478927 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] | 0.590 |
INTS4 | FAM118B | ENSP00000434466 | ENSP00000433343 | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | 0.461 |
MAMLD1 | C11orf95 | ENSP00000414517 | ENSP00000482180 | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family. | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | 0.747 |
MAMLD1 | FAM118B | ENSP00000414517 | ENSP00000433343 | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family. | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | 0.822 |
MAMLD1 | YAP1 | ENSP00000414517 | ENSP00000478927 | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family. | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] | 0.512 |
MED7 | FAM118B | ENSP00000286317 | ENSP00000433343 | Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | 0.451 |