node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD55 | ARL15 | ENSP00000342295 | ENSP00000433427 | Ankyrin repeat domain 55. | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | 0.610 |
ANKRD55 | FAM13A | ENSP00000342295 | ENSP00000264344 | Ankyrin repeat domain 55. | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.449 |
ANKRD55 | GRB14 | ENSP00000342295 | ENSP00000263915 | Ankyrin repeat domain 55. | Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. | 0.612 |
ANKRD55 | LYPLAL1 | ENSP00000342295 | ENSP00000355895 | Ankyrin repeat domain 55. | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.523 |
ARL15 | ANKRD55 | ENSP00000433427 | ENSP00000342295 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Ankyrin repeat domain 55. | 0.610 |
ARL15 | CNNM1 | ENSP00000433427 | ENSP00000349147 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | 0.527 |
ARL15 | CNNM2 | ENSP00000433427 | ENSP00000358894 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | 0.532 |
ARL15 | FAM13A | ENSP00000433427 | ENSP00000264344 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.561 |
ARL15 | GRB14 | ENSP00000433427 | ENSP00000263915 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. | 0.559 |
ARL15 | ITSN1 | ENSP00000433427 | ENSP00000370719 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...] | 0.539 |
ARL15 | ITSN2 | ENSP00000433427 | ENSP00000347244 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.536 |
ARL15 | LYPLAL1 | ENSP00000433427 | ENSP00000355895 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.606 |
ARL15 | PTP4A1 | ENSP00000433427 | ENSP00000497588 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.718 |
ARL15 | PTP4A2 | ENSP00000433427 | ENSP00000493688 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.521 |
CNNM1 | ARL15 | ENSP00000349147 | ENSP00000433427 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | 0.527 |
CNNM1 | PTP4A1 | ENSP00000349147 | ENSP00000497588 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.734 |
CNNM1 | PTP4A2 | ENSP00000349147 | ENSP00000493688 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.786 |
CNNM2 | ARL15 | ENSP00000358894 | ENSP00000433427 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family. | 0.532 |
CNNM2 | PTP4A1 | ENSP00000358894 | ENSP00000497588 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.970 |
CNNM2 | PTP4A2 | ENSP00000358894 | ENSP00000493688 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.795 |