STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPIPA5Nuclear pore complex interacting protein family member A5 (350 aa)    
Predicted Functional Partners:
FAM71A
Protein FAM71A; Family with sequence similarity 71 member A; Belongs to the FAM71 family
      
 0.669
DDX26B
Integrator complex subunit 6-like; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
      
 0.632
KBTBD7
Kelch repeat and BTB domain containing 7
      
 0.630
BCDIN3D
Pre-miRNA 5'-monophosphate methyltransferase; O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre- miRNAs
      
 0.545
ZNF787
Zinc finger protein 787; May be involved in transcriptional regulation; Zinc fingers C2H2-type
      
 0.540
HECW2
E3 ubiquitin-protein ligase HECW2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition; C2 domain containing
      
 0.530
ADAMTS8
A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties; ADAM metallopeptidases with thrombospondin type 1 motif
   
  
 0.454
HSPB7
Heat shock protein family B member 7
      
 0.447
PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes; C2 domain containing phospholipases
   
  
 0.439
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (12%) [HD]