STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPAN19Putative tetraspanin-19; Tetraspanin 19. (248 aa)    
Predicted Functional Partners:
C7orf77
Uncharacterized protein C7orf77; Chromosome 7 open reading frame 77.
      
 0.582
TSPAN2
Tetraspanin-2; May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath; Belongs to the tetraspanin (TM4SF) family.
      
 0.539
LRRIQ1
Leucine rich repeats and IQ motif containing 1.
   
  
 0.532
FAM216B
Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family.
   
  
 0.518
TSPAN32
Tetraspanin-32; Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family.
      
 0.503
OVCH1
Ovochymase-1; Ovochymase 1.
      
 0.466
WDR87
WD repeat domain 87.
  
     0.460
TMEM212
Transmembrane protein 212.
   
  
 0.455
TSPAN16
Tetraspanin-16; Tetraspanin 16.
      
0.447
CD81
CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...]
      
 0.424
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.