STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF623Zinc finger protein 623; May be involved in transcriptional regulation. (536 aa)    
Predicted Functional Partners:
C19orf25
UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family.
      
 0.520
C8orf76
Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.
   
  
 0.497
ARHGAP39
Rho GTPase activating protein 39.
   
 
 0.494
POP1
Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
   
 
 0.491
ZHX1-C8orf76
Zinc fingers and homeoboxes protein 1, isoform 2; ZHX1-C8orf76 readthrough.
      
 0.479
TIGD5
Tigger transposable element derived 5.
   
  
 0.461
C8orf33
UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.
   
  
 0.459
COMMD5
COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B.
   
  
 0.450
C14orf180
Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180.
      
 0.439
FAM83H
Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration.
   
  
 0.404
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.