node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALKBH8 | KBTBD3 | ENSP00000397673 | ENSP00000432163 | Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in [...] | Kelch repeat and BTB domain containing 3. | 0.588 |
GPR22 | KBTBD3 | ENSP00000302676 | ENSP00000432163 | G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity). | Kelch repeat and BTB domain containing 3. | 0.454 |
KBTBD3 | ALKBH8 | ENSP00000432163 | ENSP00000397673 | Kelch repeat and BTB domain containing 3. | Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in [...] | 0.588 |
KBTBD3 | GPR22 | ENSP00000432163 | ENSP00000302676 | Kelch repeat and BTB domain containing 3. | G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity). | 0.454 |
KBTBD3 | MSANTD4 | ENSP00000432163 | ENSP00000304713 | Kelch repeat and BTB domain containing 3. | Myb/SANT-like DNA-binding domain-containing protein 4; Myb/SANT DNA binding domain containing 4 with coiled-coils. | 0.534 |
KBTBD3 | SIKE1 | ENSP00000432163 | ENSP00000358541 | Kelch repeat and BTB domain containing 3. | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways; Belongs to the SIKE family. | 0.521 |
KBTBD3 | SP110 | ENSP00000432163 | ENSP00000258381 | Kelch repeat and BTB domain containing 3. | Sp110 nuclear body protein; Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). | 0.525 |
KBTBD3 | SRM | ENSP00000432163 | ENSP00000366156 | Kelch repeat and BTB domain containing 3. | Spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3- diaminopropane. Has extremely low activity towards spermidine. | 0.487 |
KBTBD3 | TMEM225B | ENSP00000432163 | ENSP00000492416 | Kelch repeat and BTB domain containing 3. | Transmembrane protein 225B. | 0.592 |
KBTBD3 | UQCRB | ENSP00000432163 | ENSP00000430494 | Kelch repeat and BTB domain containing 3. | Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] | 0.505 |
KBTBD3 | UQCRQ | ENSP00000432163 | ENSP00000367939 | Kelch repeat and BTB domain containing 3. | Cytochrome b-c1 complex subunit 8; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] | 0.449 |
KBTBD3 | ZC3H12C | ENSP00000432163 | ENSP00000278590 | Kelch repeat and BTB domain containing 3. | Probable ribonuclease ZC3H12C; May function as RNase and regulate the levels of target RNA species; Belongs to the ZC3H12 family. | 0.546 |
MSANTD4 | KBTBD3 | ENSP00000304713 | ENSP00000432163 | Myb/SANT-like DNA-binding domain-containing protein 4; Myb/SANT DNA binding domain containing 4 with coiled-coils. | Kelch repeat and BTB domain containing 3. | 0.534 |
SIKE1 | KBTBD3 | ENSP00000358541 | ENSP00000432163 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways; Belongs to the SIKE family. | Kelch repeat and BTB domain containing 3. | 0.521 |
SP110 | KBTBD3 | ENSP00000258381 | ENSP00000432163 | Sp110 nuclear body protein; Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). | Kelch repeat and BTB domain containing 3. | 0.525 |
SRM | KBTBD3 | ENSP00000366156 | ENSP00000432163 | Spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3- diaminopropane. Has extremely low activity towards spermidine. | Kelch repeat and BTB domain containing 3. | 0.487 |
TMEM225B | KBTBD3 | ENSP00000492416 | ENSP00000432163 | Transmembrane protein 225B. | Kelch repeat and BTB domain containing 3. | 0.592 |
UQCRB | KBTBD3 | ENSP00000430494 | ENSP00000432163 | Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] | Kelch repeat and BTB domain containing 3. | 0.505 |
UQCRB | UQCRQ | ENSP00000430494 | ENSP00000367939 | Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] | Cytochrome b-c1 complex subunit 8; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] | 0.999 |
UQCRQ | KBTBD3 | ENSP00000367939 | ENSP00000432163 | Cytochrome b-c1 complex subunit 8; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] | Kelch repeat and BTB domain containing 3. | 0.449 |