Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CCDC166Coiled-coil domain containing 166. (439 aa)    
Predicted Functional Partners:
WDR97
WD repeat domain 97.
  
   
 0.544
ASPHD1
Aspartate beta-hydroxylase domain containing 1.
      
 0.527
ZNF707
Zinc finger protein 707; May be involved in transcriptional regulation.
      
 0.500
C13orf42
Uncharacterized protein C13orf42; Chromosome 13 open reading frame 42.
      
 0.466
ITM2B
Integral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers; Belongs to the ITM2 family.
    
 
 0.456
CLEC20A
C-type lectin domain containing 20A.
      
 0.441
ARHGAP39
Rho GTPase activating protein 39.
      
 0.440
SPATA31A1
Spermatogenesis-associated protein 31A1; May play a role in spermatogenesis; Belongs to the SPATA31 family.
      
 0.429
SPATA31A3
Spermatogenesis-associated protein 31A3; May play a role in spermatogenesis; Belongs to the SPATA31 family.
      
 0.426
SYT11
Synaptotagmin-11; Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin- mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of a [...]
      
 0.414
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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