C12orf43 protein (human) - STRING interaction network

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C12orf43

Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development. (293 aa)

Predicted Functional Partners:

CRCP

0.778

CINP

0.774

KRIT1

0.597

FAM78B

0.550

ANKRD13A

0.536

SNRNP35

0.533

RPP14

0.489

METTL2B

0.480

GPHA2

0.478

FRMD8

0.471

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD13A	C12orf43	ENSP00000261739	ENSP00000442224	Ankyrin repeat domain-containing protein 13A; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	0.536
ANKRD13A	GPHA2	ENSP00000261739	ENSP00000279168	Ankyrin repeat domain-containing protein 13A; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. Belongs to the glycoprotein hormones subunit alpha family.	0.433
C12orf43	ANKRD13A	ENSP00000442224	ENSP00000261739	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	Ankyrin repeat domain-containing protein 13A; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	0.536
C12orf43	CINP	ENSP00000442224	ENSP00000216756	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. Belongs to the CINP family.	0.774
C12orf43	CRCP	ENSP00000442224	ENSP00000378736	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	DNA-directed RNA polymerase III subunit RPC9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type [...]	0.778
C12orf43	FAM78B	ENSP00000442224	ENSP00000346404	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	Protein FAM78B; Family with sequence similarity 78 member B; Belongs to the FAM78 family.	0.550
C12orf43	FRMD8	ENSP00000442224	ENSP00000319726	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6.	0.471
C12orf43	GPHA2	ENSP00000442224	ENSP00000279168	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. Belongs to the glycoprotein hormones subunit alpha family.	0.478
C12orf43	KRIT1	ENSP00000442224	ENSP00000378015	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH- dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and v [...]	0.597
C12orf43	METTL2B	ENSP00000442224	ENSP00000262432	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	0.480
C12orf43	RPP14	ENSP00000442224	ENSP00000412894	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	Ribonuclease P protein subunit p14; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	0.489
C12orf43	SNRNP35	ENSP00000442224	ENSP00000403310	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	Small nuclear ribonucleoprotein U11/U12 subunit 35.	0.533
CINP	C12orf43	ENSP00000216756	ENSP00000442224	Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. Belongs to the CINP family.	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	0.774
CINP	CRCP	ENSP00000216756	ENSP00000378736	Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. Belongs to the CINP family.	DNA-directed RNA polymerase III subunit RPC9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type [...]	0.427
CINP	SNRNP35	ENSP00000216756	ENSP00000403310	Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. Belongs to the CINP family.	Small nuclear ribonucleoprotein U11/U12 subunit 35.	0.483
CRCP	C12orf43	ENSP00000378736	ENSP00000442224	DNA-directed RNA polymerase III subunit RPC9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type [...]	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	0.778
CRCP	CINP	ENSP00000378736	ENSP00000216756	DNA-directed RNA polymerase III subunit RPC9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type [...]	Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. Belongs to the CINP family.	0.427
CRCP	METTL2B	ENSP00000378736	ENSP00000262432	DNA-directed RNA polymerase III subunit RPC9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type [...]	tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family.	0.655
CRCP	RPP14	ENSP00000378736	ENSP00000412894	DNA-directed RNA polymerase III subunit RPC9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type [...]	Ribonuclease P protein subunit p14; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	0.439
FAM78B	C12orf43	ENSP00000346404	ENSP00000442224	Protein FAM78B; Family with sequence similarity 78 member B; Belongs to the FAM78 family.	Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.	0.550