node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP4E1 | HEATR5A | ENSP00000261842 | ENSP00000437968 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | HEAT repeat containing 5A. | 0.456 |
DTD2 | GPR33 | ENSP00000312224 | ENSP00000421557 | D-aminoacyl-tRNA deacylase 2; Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl- tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the format [...] | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.570 |
DTD2 | HEATR5A | ENSP00000312224 | ENSP00000437968 | D-aminoacyl-tRNA deacylase 2; Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl- tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the format [...] | HEAT repeat containing 5A. | 0.630 |
EVI5 | HEATR5A | ENSP00000440826 | ENSP00000437968 | Ecotropic viral integration site 5 protein homolog; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. | HEAT repeat containing 5A. | 0.478 |
FAM170B | HEATR5A | ENSP00000308292 | ENSP00000437968 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | HEAT repeat containing 5A. | 0.463 |
GPR33 | DTD2 | ENSP00000421557 | ENSP00000312224 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family. | D-aminoacyl-tRNA deacylase 2; Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl- tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the format [...] | 0.570 |
GPR33 | HEATR5A | ENSP00000421557 | ENSP00000437968 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family. | HEAT repeat containing 5A. | 0.478 |
HEATR5A | AP4E1 | ENSP00000437968 | ENSP00000261842 | HEAT repeat containing 5A. | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | 0.456 |
HEATR5A | DTD2 | ENSP00000437968 | ENSP00000312224 | HEAT repeat containing 5A. | D-aminoacyl-tRNA deacylase 2; Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl- tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the format [...] | 0.630 |
HEATR5A | EVI5 | ENSP00000437968 | ENSP00000440826 | HEAT repeat containing 5A. | Ecotropic viral integration site 5 protein homolog; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. | 0.478 |
HEATR5A | FAM170B | ENSP00000437968 | ENSP00000308292 | HEAT repeat containing 5A. | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | 0.463 |
HEATR5A | GPR33 | ENSP00000437968 | ENSP00000421557 | HEAT repeat containing 5A. | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.478 |
HEATR5A | IQCB1 | ENSP00000437968 | ENSP00000311505 | HEAT repeat containing 5A. | IQ calmodulin-binding motif-containing protein 1; Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6. | 0.446 |
HEATR5A | IQCJ | ENSP00000437968 | ENSP00000402153 | HEAT repeat containing 5A. | IQ motif containing J. | 0.461 |
HEATR5A | KIF6 | ENSP00000437968 | ENSP00000287152 | HEAT repeat containing 5A. | Kinesin-like protein KIF6; Kinesin family member 6. | 0.604 |
HEATR5A | SLC30A6 | ENSP00000437968 | ENSP00000368648 | HEAT repeat containing 5A. | Zinc transporter 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.471 |
HEATR5A | UEVLD | ENSP00000437968 | ENSP00000379500 | HEAT repeat containing 5A. | Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination. In the N-terminal section; belongs to the ubiquitin- conjugating enzyme family. UEV subfamily. | 0.459 |
IQCB1 | HEATR5A | ENSP00000311505 | ENSP00000437968 | IQ calmodulin-binding motif-containing protein 1; Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6. | HEAT repeat containing 5A. | 0.446 |
IQCJ | HEATR5A | ENSP00000402153 | ENSP00000437968 | IQ motif containing J. | HEAT repeat containing 5A. | 0.461 |
KIF6 | HEATR5A | ENSP00000287152 | ENSP00000437968 | Kinesin-like protein KIF6; Kinesin family member 6. | HEAT repeat containing 5A. | 0.604 |