STRINGSTRING
MDH1 protein (human) - STRING interaction network
"MDH1" - Malate dehydrogenase 1, NAD in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MDH1Malate dehydrogenase 1, NAD (soluble) (352 aa)    
Predicted Functional Partners:
ACLY
ATP citrate lyase; ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
   
  0.999
GOT1
Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] (413 aa)
     
  0.994
CS
Citrate synthase (466 aa)
   
  0.993
ME3
Malic enzyme 3, NADP(+)-dependent, mitochondrial (604 aa)
   
  0.992
ME1
Malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa)
   
  0.992
MDH2
Malate dehydrogenase 2, NAD (mitochondrial) (338 aa)
     
 
  0.991
ME2
Malic enzyme 2, NAD(+)-dependent, mitochondrial (584 aa)
   
  0.990
FH
Fumarate hydratase; Also acts as a tumor suppressor (510 aa)
   
  0.990
GOT2
Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (430 aa)
     
  0.988
PCK1
Phosphoenolpyruvate carboxykinase 1 (soluble); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (622 aa)
     
 
  0.971
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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