node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2L14 | MANSC1 | ENSP00000309132 | ENSP00000438205 | Apoptosis facilitator Bcl-2-like protein 14; Plays a role in apoptosis. | MANSC domain containing 1. | 0.546 |
BORCS5 | CREBL2 | ENSP00000321546 | ENSP00000228865 | BLOC-1-related complex subunit 5; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily. | 0.554 |
BORCS5 | MANSC1 | ENSP00000321546 | ENSP00000438205 | BLOC-1-related complex subunit 5; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. | MANSC domain containing 1. | 0.451 |
C10orf71 | MANSC1 | ENSP00000363259 | ENSP00000438205 | Cardiac-enriched FHL2-interacting protein; Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. | MANSC domain containing 1. | 0.460 |
C3orf62 | MANSC1 | ENSP00000341139 | ENSP00000438205 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62. | MANSC domain containing 1. | 0.453 |
CMTM6 | MANSC1 | ENSP00000205636 | ENSP00000438205 | CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ul [...] | MANSC domain containing 1. | 0.467 |
CREBL2 | BORCS5 | ENSP00000228865 | ENSP00000321546 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily. | BLOC-1-related complex subunit 5; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. | 0.554 |
CREBL2 | FAM234B | ENSP00000228865 | ENSP00000197268 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily. | Protein FAM234B; Family with sequence similarity 234 member B. | 0.407 |
CREBL2 | MANSC1 | ENSP00000228865 | ENSP00000438205 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily. | MANSC domain containing 1. | 0.510 |
FAM189A2 | MANSC1 | ENSP00000304435 | ENSP00000438205 | Protein FAM189A2; Family with sequence similarity 189 member A2. | MANSC domain containing 1. | 0.469 |
FAM234B | CREBL2 | ENSP00000197268 | ENSP00000228865 | Protein FAM234B; Family with sequence similarity 234 member B. | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily. | 0.407 |
FAM234B | MANSC1 | ENSP00000197268 | ENSP00000438205 | Protein FAM234B; Family with sequence similarity 234 member B. | MANSC domain containing 1. | 0.448 |
MANSC1 | BCL2L14 | ENSP00000438205 | ENSP00000309132 | MANSC domain containing 1. | Apoptosis facilitator Bcl-2-like protein 14; Plays a role in apoptosis. | 0.546 |
MANSC1 | BORCS5 | ENSP00000438205 | ENSP00000321546 | MANSC domain containing 1. | BLOC-1-related complex subunit 5; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. | 0.451 |
MANSC1 | C10orf71 | ENSP00000438205 | ENSP00000363259 | MANSC domain containing 1. | Cardiac-enriched FHL2-interacting protein; Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. | 0.460 |
MANSC1 | C3orf62 | ENSP00000438205 | ENSP00000341139 | MANSC domain containing 1. | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62. | 0.453 |
MANSC1 | CMTM6 | ENSP00000438205 | ENSP00000205636 | MANSC domain containing 1. | CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ul [...] | 0.467 |
MANSC1 | CREBL2 | ENSP00000438205 | ENSP00000228865 | MANSC domain containing 1. | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily. | 0.510 |
MANSC1 | FAM189A2 | ENSP00000438205 | ENSP00000304435 | MANSC domain containing 1. | Protein FAM189A2; Family with sequence similarity 189 member A2. | 0.469 |
MANSC1 | FAM234B | ENSP00000438205 | ENSP00000197268 | MANSC domain containing 1. | Protein FAM234B; Family with sequence similarity 234 member B. | 0.448 |