Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ZNF426Zinc finger protein 426; May be involved in transcriptional regulation. (554 aa)    
Predicted Functional Partners:
MAGOHB
Protein mago nashi homolog 2; Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway.
   
   0.841
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]
   
 0.770
ZNF778
Zinc finger protein 778; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
  
0.770
ZNF439
Zinc finger protein 439; May be involved in transcriptional regulation.
  
   
0.748
ZNF563
Zinc finger protein 563; May be involved in transcriptional regulation.
  
   
0.744
ZNF69-2
Zinc finger protein 69; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
   
0.744
ZNF625
Zinc finger protein 625; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
   
0.742
ZNF20
Zinc finger protein 20; May be involved in transcriptional regulation.
  
   
0.696
TXLNG
Gamma-taxilin; May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.
    
   0.633
ZNF382
Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family.
  
  
0.616
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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