FMC1-LUC7L2 protein (human) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FMC1-LUC7L2	LUC7L	ENSP00000440222	ENSP00000293872	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	0.943
FMC1-LUC7L2	PRPF39	ENSP00000440222	ENSP00000348010	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing.	0.812
FMC1-LUC7L2	PRPF40B	ENSP00000440222	ENSP00000448073	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing.	0.833
FMC1-LUC7L2	RBM25	ENSP00000440222	ENSP00000261973	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...]	0.814
FMC1-LUC7L2	SCNM1	ENSP00000440222	ENSP00000357901	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.	0.927
FMC1-LUC7L2	SNRNP70	ENSP00000440222	ENSP00000472998	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.	0.928
FMC1-LUC7L2	SNRPC	ENSP00000440222	ENSP00000244520	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...]	0.910
FMC1-LUC7L2	SNRPD2	ENSP00000440222	ENSP00000342374	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.	0.922
FMC1-LUC7L2	SNRPN	ENSP00000440222	ENSP00000494831	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events.	0.820
FMC1-LUC7L2	U2AF2	ENSP00000440222	ENSP00000307863	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...]	0.815
LUC7L	FMC1-LUC7L2	ENSP00000293872	ENSP00000440222	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.	0.943
LUC7L	PRPF39	ENSP00000293872	ENSP00000348010	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing.	0.979
LUC7L	PRPF40B	ENSP00000293872	ENSP00000448073	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing.	0.964
LUC7L	RBM25	ENSP00000293872	ENSP00000261973	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...]	0.933
LUC7L	SCNM1	ENSP00000293872	ENSP00000357901	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.	0.547
LUC7L	SNRNP70	ENSP00000293872	ENSP00000472998	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.	0.997
LUC7L	SNRPC	ENSP00000293872	ENSP00000244520	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...]	0.991
LUC7L	SNRPD2	ENSP00000293872	ENSP00000342374	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.	0.994
LUC7L	SNRPN	ENSP00000293872	ENSP00000494831	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events.	0.972
LUC7L	U2AF2	ENSP00000293872	ENSP00000307863	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...]	0.987