node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FMC1-LUC7L2 | PRPF40B | ENSP00000440222 | ENSP00000448073 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | 0.874 |
FMC1-LUC7L2 | RBM25 | ENSP00000440222 | ENSP00000261973 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | 0.894 |
FMC1-LUC7L2 | SCNM1 | ENSP00000440222 | ENSP00000357901 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites. | 0.926 |
FMC1-LUC7L2 | SNRNP70 | ENSP00000440222 | ENSP00000472998 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.956 |
FMC1-LUC7L2 | SNRPA1 | ENSP00000440222 | ENSP00000254193 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. Belongs to the U2 small nuclear ribonucleoprotein A family. | 0.854 |
FMC1-LUC7L2 | SNRPC | ENSP00000440222 | ENSP00000244520 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] | 0.936 |
FMC1-LUC7L2 | SNRPD1 | ENSP00000440222 | ENSP00000300413 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with R [...] | 0.875 |
FMC1-LUC7L2 | SNRPD2 | ENSP00000440222 | ENSP00000342374 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. | 0.949 |
FMC1-LUC7L2 | SNRPF | ENSP00000440222 | ENSP00000266735 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. | 0.857 |
FMC1-LUC7L2 | SNRPN | ENSP00000440222 | ENSP00000494831 | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events. | 0.866 |
PRPF40B | FMC1-LUC7L2 | ENSP00000448073 | ENSP00000440222 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | 0.874 |
PRPF40B | RBM25 | ENSP00000448073 | ENSP00000261973 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | 0.990 |
PRPF40B | SNRNP70 | ENSP00000448073 | ENSP00000472998 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.932 |
PRPF40B | SNRPA1 | ENSP00000448073 | ENSP00000254193 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. Belongs to the U2 small nuclear ribonucleoprotein A family. | 0.857 |
PRPF40B | SNRPC | ENSP00000448073 | ENSP00000244520 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] | 0.944 |
PRPF40B | SNRPD1 | ENSP00000448073 | ENSP00000300413 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with R [...] | 0.929 |
PRPF40B | SNRPD2 | ENSP00000448073 | ENSP00000342374 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. | 0.834 |
PRPF40B | SNRPF | ENSP00000448073 | ENSP00000266735 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. | 0.915 |
PRPF40B | SNRPN | ENSP00000448073 | ENSP00000494831 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing. | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events. | 0.906 |
RBM25 | FMC1-LUC7L2 | ENSP00000261973 | ENSP00000440222 | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough. | 0.894 |