KIAA1958 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B4GALT6	KIAA1958	ENSP00000306459	ENSP00000440504	Beta-1,4-galactosyltransferase 6; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Belongs to the glycosyltransferase 7 family.	Uncharacterized protein KIAA1958; KIAA1958.	0.616
B4GALT6	SETD4	ENSP00000306459	ENSP00000382163	Beta-1,4-galactosyltransferase 6; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Belongs to the glycosyltransferase 7 family.	SET domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.	0.518
FAM199X	KIAA1958	ENSP00000417581	ENSP00000440504	Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family.	Uncharacterized protein KIAA1958; KIAA1958.	0.495
GABARAPL2	KIAA1958	ENSP00000037243	ENSP00000440504	Gamma-aminobutyric acid receptor-associated protein-like 2; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved [...]	Uncharacterized protein KIAA1958; KIAA1958.	0.562
GASK1A	KIAA1958	ENSP00000407301	ENSP00000440504	Golgi associated kinase 1A; Belongs to the GASK family.	Uncharacterized protein KIAA1958; KIAA1958.	0.544
GASK1A	STMND1	ENSP00000407301	ENSP00000455698	Golgi associated kinase 1A; Belongs to the GASK family.	Stathmin domain containing 1.	0.606
GASK1A	TTC22	ENSP00000407301	ENSP00000360323	Golgi associated kinase 1A; Belongs to the GASK family.	Tetratricopeptide repeat domain 22.	0.501
KIAA1958	B4GALT6	ENSP00000440504	ENSP00000306459	Uncharacterized protein KIAA1958; KIAA1958.	Beta-1,4-galactosyltransferase 6; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Belongs to the glycosyltransferase 7 family.	0.616
KIAA1958	FAM199X	ENSP00000440504	ENSP00000417581	Uncharacterized protein KIAA1958; KIAA1958.	Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family.	0.495
KIAA1958	GABARAPL2	ENSP00000440504	ENSP00000037243	Uncharacterized protein KIAA1958; KIAA1958.	Gamma-aminobutyric acid receptor-associated protein-like 2; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved [...]	0.562
KIAA1958	GASK1A	ENSP00000440504	ENSP00000407301	Uncharacterized protein KIAA1958; KIAA1958.	Golgi associated kinase 1A; Belongs to the GASK family.	0.544
KIAA1958	SETD4	ENSP00000440504	ENSP00000382163	Uncharacterized protein KIAA1958; KIAA1958.	SET domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.	0.660
KIAA1958	SOCS3	ENSP00000440504	ENSP00000330341	Uncharacterized protein KIAA1958; KIAA1958.	Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL [...]	0.772
KIAA1958	STAC	ENSP00000440504	ENSP00000273183	Uncharacterized protein KIAA1958; KIAA1958.	SH3 and cysteine-rich domain-containing protein; Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.	0.550
KIAA1958	STMND1	ENSP00000440504	ENSP00000455698	Uncharacterized protein KIAA1958; KIAA1958.	Stathmin domain containing 1.	0.585
KIAA1958	TTC22	ENSP00000440504	ENSP00000360323	Uncharacterized protein KIAA1958; KIAA1958.	Tetratricopeptide repeat domain 22.	0.498
KIAA1958	TTC38	ENSP00000440504	ENSP00000370419	Uncharacterized protein KIAA1958; KIAA1958.	Tetratricopeptide repeat domain 38; Belongs to the TTC38 family.	0.528
SETD4	B4GALT6	ENSP00000382163	ENSP00000306459	SET domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.	Beta-1,4-galactosyltransferase 6; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Belongs to the glycosyltransferase 7 family.	0.518
SETD4	KIAA1958	ENSP00000382163	ENSP00000440504	SET domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.	Uncharacterized protein KIAA1958; KIAA1958.	0.660
SOCS3	KIAA1958	ENSP00000330341	ENSP00000440504	Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL [...]	Uncharacterized protein KIAA1958; KIAA1958.	0.772