STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CACFD1Calcium channel flower domain containing 1. (233 aa)    
Predicted Functional Partners:
TMEM159
Promethin; Transmembrane protein 159; Belongs to the TMEM159 family.
    
   0.603
FAM163B
Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.
      
 0.493
MRFAP1L1
Morf4 family associated protein 1 like 1.
      
 0.426
RETREG3
Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth. Belongs to the RETREG family.
   
  
 0.422
C1orf35
Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35.
   
  
 0.416
C9orf72
Guanine nucleotide exchange C9orf72; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP- bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity. Positivel [...]
      
 0.414
FAM163A
Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family.
      
 0.407
C6orf47
Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47.
   
  
 0.404
GOLGA8K
Golgin A8 family member K; Belongs to the GOLGA8 family.
      
 0.400
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.