node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AQP6 | RHBG | ENSP00000320247 | ENSP00000441197 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | 0.513 |
FAM187A | RHBG | ENSP00000329499 | ENSP00000441197 | Ig-like V-type domain-containing protein FAM187A; Family with sequence similarity 187 member A. | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | 0.466 |
GLUL | RHBG | ENSP00000307900 | ENSP00000441197 | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | 0.501 |
RHBG | AQP6 | ENSP00000441197 | ENSP00000320247 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. | 0.513 |
RHBG | FAM187A | ENSP00000441197 | ENSP00000329499 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Ig-like V-type domain-containing protein FAM187A; Family with sequence similarity 187 member A. | 0.466 |
RHBG | GLUL | ENSP00000441197 | ENSP00000307900 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane locali [...] | 0.501 |
RHBG | SLC12A1 | ENSP00000441197 | ENSP00000495332 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. | 0.517 |
RHBG | SLC26A4 | ENSP00000441197 | ENSP00000494017 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.576 |
RHBG | SLC4A4 | ENSP00000441197 | ENSP00000393557 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Belongs to the anion exchanger (TC 2.A.31) family. | 0.436 |
RHBG | SLC9A2 | ENSP00000441197 | ENSP00000233969 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Sodium/hydrogen exchanger 2; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. | 0.636 |
RHBG | SLC9A3 | ENSP00000441197 | ENSP00000264938 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. | 0.630 |
RHBG | SLC9A4 | ENSP00000441197 | ENSP00000295269 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Sodium/hydrogen exchanger 4; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained int [...] | 0.526 |
RHBG | SORD | ENSP00000441197 | ENSP00000267814 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is mostly active with D- sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D- xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as d [...] | 0.420 |
SLC12A1 | RHBG | ENSP00000495332 | ENSP00000441197 | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | 0.517 |
SLC12A1 | SLC26A4 | ENSP00000495332 | ENSP00000494017 | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. | Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.619 |
SLC12A1 | SLC4A4 | ENSP00000495332 | ENSP00000393557 | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Belongs to the anion exchanger (TC 2.A.31) family. | 0.618 |
SLC12A1 | SLC9A2 | ENSP00000495332 | ENSP00000233969 | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. | Sodium/hydrogen exchanger 2; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. | 0.577 |
SLC12A1 | SLC9A3 | ENSP00000495332 | ENSP00000264938 | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. | 0.852 |
SLC12A1 | SLC9A4 | ENSP00000495332 | ENSP00000295269 | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. | Sodium/hydrogen exchanger 4; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained int [...] | 0.566 |
SLC26A4 | RHBG | ENSP00000494017 | ENSP00000441197 | Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Ammonium transporter Rh type B; Functions as a specific ammonium transporter. | 0.576 |