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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MSLNLMesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family. (752 aa)    
Predicted Functional Partners:
OR10K2
Olfactory receptor 10K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.512
UMODL1
Uromodulin like 1.
      
 0.507
ABCA10
ATP-binding cassette sub-family A member 10; Probable transporter which may play a role in macrophage lipid homeostasis.
      
 0.489
OR10T2
Olfactory receptor 10T2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.476
OR10K1
Olfactory receptor 10K1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.473
TMEM211
Transmembrane protein 211.
      
 0.453
GRAMD1C
Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol [...]
      
 0.447
TTC9
Tetratricopeptide repeat domain 9; Belongs to the TTC9 family.
      
 0.431
FAM13C
Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family.
      
 0.429
SARM1
NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+ [...]
      
 0.417
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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