node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA1C | CSMD1 | ENSP00000266376 | ENSP00000489225 | Voltage-dependent L-type calcium channel subunit alpha-1C; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via [...] | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | 0.546 |
CACNA1C | NT5C2 | ENSP00000266376 | ENSP00000339479 | Voltage-dependent L-type calcium channel subunit alpha-1C; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via [...] | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | 0.498 |
CACNA1C | TENM4 | ENSP00000266376 | ENSP00000278550 | Voltage-dependent L-type calcium channel subunit alpha-1C; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via [...] | Teneurin-4; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity); Belongs to the tenascin family. Teneurin subfamily. | 0.638 |
CACNA1C | WBP1L | ENSP00000266376 | ENSP00000414721 | Voltage-dependent L-type calcium channel subunit alpha-1C; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via [...] | WW domain binding protein 1 like. | 0.573 |
CACNA1C | ZNF804A | ENSP00000266376 | ENSP00000303252 | Voltage-dependent L-type calcium channel subunit alpha-1C; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via [...] | Zinc finger protein 804A. | 0.699 |
CSMD1 | CACNA1C | ENSP00000489225 | ENSP00000266376 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | Voltage-dependent L-type calcium channel subunit alpha-1C; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via [...] | 0.546 |
CSMD1 | LRP1B | ENSP00000489225 | ENSP00000374135 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. | 0.593 |
CSMD1 | NT5C2 | ENSP00000489225 | ENSP00000339479 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | 0.568 |
CSMD1 | PTPRD | ENSP00000489225 | ENSP00000370593 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2; Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | 0.556 |
CSMD1 | PTPRT | ENSP00000489225 | ENSP00000362294 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | Receptor-type tyrosine-protein phosphatase T; May be involved in both signal transduction and cellular adhesion in the CNS; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. | 0.557 |
CSMD1 | SERPINB8 | ENSP00000489225 | ENSP00000331368 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | Serpin B8; Has an important role in epithelial desmosome-mediated cell- cell adhesion; Belongs to the serpin family. Ov-serpin subfamily. | 0.535 |
CSMD1 | SLC35F2 | ENSP00000489225 | ENSP00000436785 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | Solute carrier family 35 member F2; Putative solute transporter. | 0.616 |
CSMD1 | TENM4 | ENSP00000489225 | ENSP00000278550 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | Teneurin-4; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity); Belongs to the tenascin family. Teneurin subfamily. | 0.530 |
CSMD1 | WBP1L | ENSP00000489225 | ENSP00000414721 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | WW domain binding protein 1 like. | 0.666 |
CSMD1 | ZNF804A | ENSP00000489225 | ENSP00000303252 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | Zinc finger protein 804A. | 0.610 |
LRP1B | CSMD1 | ENSP00000374135 | ENSP00000489225 | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | 0.593 |
LRP1B | PTPRD | ENSP00000374135 | ENSP00000370593 | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2; Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | 0.746 |
LRP1B | PTPRT | ENSP00000374135 | ENSP00000362294 | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. | Receptor-type tyrosine-protein phosphatase T; May be involved in both signal transduction and cellular adhesion in the CNS; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. | 0.495 |
NT5C2 | CACNA1C | ENSP00000339479 | ENSP00000266376 | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | Voltage-dependent L-type calcium channel subunit alpha-1C; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via [...] | 0.498 |
NT5C2 | CSMD1 | ENSP00000339479 | ENSP00000489225 | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas. | 0.568 |