node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ETFB | N4BP2 | ENSP00000346173 | ENSP00000261435 | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. | NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. | 0.413 |
ETFB | ZNF567 | ENSP00000346173 | ENSP00000441838 | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.472 |
MAP3K20 | ZNF567 | ENSP00000364361 | ENSP00000441838 | Mitogen-activated protein kinase kinase kinase 20; Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Involved in limb development. | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.834 |
N4BP2 | ETFB | ENSP00000261435 | ENSP00000346173 | NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. | 0.413 |
N4BP2 | ZNF567 | ENSP00000261435 | ENSP00000441838 | NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.553 |
N4BP2 | ZWILCH | ENSP00000261435 | ENSP00000311429 | NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. | Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Belongs to the ZWILCH family. | 0.426 |
PRDX6 | ZNF567 | ENSP00000342026 | ENSP00000441838 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.443 |
SPEF1 | ZNF567 | ENSP00000369080 | ENSP00000441838 | Sperm flagellar protein 1; Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.448 |
SYCE1L | ZNF567 | ENSP00000367911 | ENSP00000441838 | Synaptonemal complex central element protein 1-like; May be involved in meiosis. | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.490 |
TRIM28 | ZNF420 | ENSP00000253024 | ENSP00000338770 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 420; May be involved in transcriptional regulation. | 0.660 |
TRIM28 | ZNF567 | ENSP00000253024 | ENSP00000441838 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.605 |
TRIM28 | ZNF675 | ENSP00000253024 | ENSP00000352836 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 675; May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity. | 0.580 |
ZNF420 | TRIM28 | ENSP00000338770 | ENSP00000253024 | Zinc finger protein 420; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.660 |
ZNF420 | ZNF567 | ENSP00000338770 | ENSP00000441838 | Zinc finger protein 420; May be involved in transcriptional regulation. | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.467 |
ZNF567 | ETFB | ENSP00000441838 | ENSP00000346173 | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. | 0.472 |
ZNF567 | MAP3K20 | ENSP00000441838 | ENSP00000364361 | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Mitogen-activated protein kinase kinase kinase 20; Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Involved in limb development. | 0.834 |
ZNF567 | N4BP2 | ENSP00000441838 | ENSP00000261435 | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. | 0.553 |
ZNF567 | PRDX6 | ENSP00000441838 | ENSP00000342026 | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | 0.443 |
ZNF567 | SPEF1 | ENSP00000441838 | ENSP00000369080 | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Sperm flagellar protein 1; Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). | 0.448 |
ZNF567 | SYCE1L | ENSP00000441838 | ENSP00000367911 | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Synaptonemal complex central element protein 1-like; May be involved in meiosis. | 0.490 |