node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN10 | BEAN1 | ENSP00000252934 | ENSP00000442793 | Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. | Protein BEAN1; Brain expressed associated with NEDD4 1. | 0.597 |
ATXN10 | PLEKHG4 | ENSP00000252934 | ENSP00000353646 | Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. | Puratrophin-1; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. | 0.679 |
BEAN1 | ATXN10 | ENSP00000442793 | ENSP00000252934 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. | 0.597 |
BEAN1 | CALB1 | ENSP00000442793 | ENSP00000265431 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | 0.688 |
BEAN1 | COQ8A | ENSP00000442793 | ENSP00000355741 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Atypical kinase COQ8A, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP. | 0.558 |
BEAN1 | MRPL55 | ENSP00000442793 | ENSP00000403614 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Mitochondrial ribosomal protein L55. | 0.474 |
BEAN1 | PLEKHG4 | ENSP00000442793 | ENSP00000353646 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Puratrophin-1; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. | 0.788 |
BEAN1 | PYURF | ENSP00000442793 | ENSP00000273968 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Protein preY, mitochondrial; PIGY upstream reading frame; Belongs to the PREY family. | 0.531 |
BEAN1 | SRSF1 | ENSP00000442793 | ENSP00000258962 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...] | 0.465 |
BEAN1 | SRSF9 | ENSP00000442793 | ENSP00000229390 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Serine/arginine-rich splicing factor 9; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. Belongs to the splicing factor SR family. | 0.760 |
BEAN1 | SYP | ENSP00000442793 | ENSP00000263233 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Synaptophysin; Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity); Belongs to the synaptophysin/synaptobrevin family. | 0.541 |
BEAN1 | UBB | ENSP00000442793 | ENSP00000478771 | Protein BEAN1; Brain expressed associated with NEDD4 1. | Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.495 |
CALB1 | BEAN1 | ENSP00000265431 | ENSP00000442793 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | Protein BEAN1; Brain expressed associated with NEDD4 1. | 0.688 |
CALB1 | PLEKHG4 | ENSP00000265431 | ENSP00000353646 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | Puratrophin-1; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. | 0.436 |
CALB1 | SYP | ENSP00000265431 | ENSP00000263233 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | Synaptophysin; Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity); Belongs to the synaptophysin/synaptobrevin family. | 0.755 |
COQ8A | BEAN1 | ENSP00000355741 | ENSP00000442793 | Atypical kinase COQ8A, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP. | Protein BEAN1; Brain expressed associated with NEDD4 1. | 0.558 |
MRPL55 | BEAN1 | ENSP00000403614 | ENSP00000442793 | Mitochondrial ribosomal protein L55. | Protein BEAN1; Brain expressed associated with NEDD4 1. | 0.474 |
PLEKHG4 | ATXN10 | ENSP00000353646 | ENSP00000252934 | Puratrophin-1; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. | Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. | 0.679 |
PLEKHG4 | BEAN1 | ENSP00000353646 | ENSP00000442793 | Puratrophin-1; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. | Protein BEAN1; Brain expressed associated with NEDD4 1. | 0.788 |
PLEKHG4 | CALB1 | ENSP00000353646 | ENSP00000265431 | Puratrophin-1; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | 0.436 |