node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL2BP | EAF1 | ENSP00000219204 | ENSP00000380054 | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family. | 0.451 |
ARL2BP | EFCAB1 | ENSP00000219204 | ENSP00000262103 | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | 0.439 |
ARL2BP | GPATCH3 | ENSP00000219204 | ENSP00000354645 | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. | G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6. | 0.435 |
ARL2BP | METTL6 | ENSP00000219204 | ENSP00000407613 | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. | tRNA N(3)-methylcytidine methyltransferase METTL6; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser); Belongs to the methyltransferase superfamily. METL family. | 0.434 |
ARL2BP | RSPRY1 | ENSP00000219204 | ENSP00000443176 | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. | Ring finger and SPRY domain containing 1. | 0.562 |
CCDC106 | FIZ1 | ENSP00000465757 | ENSP00000221665 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity. | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | 0.554 |
CCDC106 | RSPRY1 | ENSP00000465757 | ENSP00000443176 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity. | Ring finger and SPRY domain containing 1. | 0.594 |
CCDC106 | ZC3H15 | ENSP00000465757 | ENSP00000338788 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity. | Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions. | 0.539 |
EAF1 | ARL2BP | ENSP00000380054 | ENSP00000219204 | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family. | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. | 0.451 |
EAF1 | EFCAB1 | ENSP00000380054 | ENSP00000262103 | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family. | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | 0.562 |
EAF1 | GPATCH3 | ENSP00000380054 | ENSP00000354645 | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family. | G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6. | 0.550 |
EAF1 | METTL6 | ENSP00000380054 | ENSP00000407613 | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family. | tRNA N(3)-methylcytidine methyltransferase METTL6; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser); Belongs to the methyltransferase superfamily. METL family. | 0.606 |
EAF1 | RSPRY1 | ENSP00000380054 | ENSP00000443176 | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family. | Ring finger and SPRY domain containing 1. | 0.601 |
EFCAB1 | ARL2BP | ENSP00000262103 | ENSP00000219204 | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. | 0.439 |
EFCAB1 | EAF1 | ENSP00000262103 | ENSP00000380054 | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family. | 0.562 |
EFCAB1 | GPATCH3 | ENSP00000262103 | ENSP00000354645 | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6. | 0.532 |
EFCAB1 | METTL6 | ENSP00000262103 | ENSP00000407613 | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | tRNA N(3)-methylcytidine methyltransferase METTL6; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser); Belongs to the methyltransferase superfamily. METL family. | 0.484 |
EFCAB1 | RSPRY1 | ENSP00000262103 | ENSP00000443176 | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | Ring finger and SPRY domain containing 1. | 0.575 |
FIZ1 | CCDC106 | ENSP00000221665 | ENSP00000465757 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity. | 0.554 |
FIZ1 | RSPRY1 | ENSP00000221665 | ENSP00000443176 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). | Ring finger and SPRY domain containing 1. | 0.563 |