node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIF2S3B | LGALS16 | ENSP00000323063 | ENSP00000375904 | Eukaryotic translation initiation factor 2 subunit gamma B. | Galectin-16; Binds lactose with high affinity. Strong inducer of T-cell apoptosis. | 0.437 |
EIF2S3B | ZNF268 | ENSP00000323063 | ENSP00000444412 | Eukaryotic translation initiation factor 2 subunit gamma B. | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.412 |
GPALPP1 | ZNF268 | ENSP00000368447 | ENSP00000444412 | GPALPP motifs containing 1. | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.461 |
LGALS16 | EIF2S3B | ENSP00000375904 | ENSP00000323063 | Galectin-16; Binds lactose with high affinity. Strong inducer of T-cell apoptosis. | Eukaryotic translation initiation factor 2 subunit gamma B. | 0.437 |
LGALS16 | ZNF268 | ENSP00000375904 | ENSP00000444412 | Galectin-16; Binds lactose with high affinity. Strong inducer of T-cell apoptosis. | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.419 |
RBPJ | ZNF268 | ENSP00000345206 | ENSP00000444412 | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.654 |
RBPJ | ZNF426 | ENSP00000345206 | ENSP00000253115 | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | Zinc finger protein 426; May be involved in transcriptional regulation. | 0.413 |
TRIM28 | ZNF26 | ENSP00000253024 | ENSP00000333725 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 26; May be involved in transcriptional regulation. | 0.583 |
TRIM28 | ZNF268 | ENSP00000253024 | ENSP00000444412 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.747 |
TRIM28 | ZNF426 | ENSP00000253024 | ENSP00000253115 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 426; May be involved in transcriptional regulation. | 0.632 |
TRIM28 | ZNF557 | ENSP00000253024 | ENSP00000252840 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.643 |
ZNF26 | TRIM28 | ENSP00000333725 | ENSP00000253024 | Zinc finger protein 26; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.583 |
ZNF26 | ZNF268 | ENSP00000333725 | ENSP00000444412 | Zinc finger protein 26; May be involved in transcriptional regulation. | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.410 |
ZNF268 | EIF2S3B | ENSP00000444412 | ENSP00000323063 | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | Eukaryotic translation initiation factor 2 subunit gamma B. | 0.412 |
ZNF268 | GPALPP1 | ENSP00000444412 | ENSP00000368447 | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | GPALPP motifs containing 1. | 0.461 |
ZNF268 | LGALS16 | ENSP00000444412 | ENSP00000375904 | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | Galectin-16; Binds lactose with high affinity. Strong inducer of T-cell apoptosis. | 0.419 |
ZNF268 | RBPJ | ENSP00000444412 | ENSP00000345206 | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | 0.654 |
ZNF268 | TRIM28 | ENSP00000444412 | ENSP00000253024 | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.747 |
ZNF268 | ZNF26 | ENSP00000444412 | ENSP00000333725 | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 26; May be involved in transcriptional regulation. | 0.410 |
ZNF268 | ZNF397 | ENSP00000444412 | ENSP00000331577 | Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor. | 0.459 |