node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMCX3 | ARMCX6 | ENSP00000340672 | ENSP00000444537 | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters; Belongs to the eutherian X-chromosome-specific Armcx family. | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | 0.431 |
ARMCX6 | ARMCX3 | ENSP00000444537 | ENSP00000340672 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters; Belongs to the eutherian X-chromosome-specific Armcx family. | 0.431 |
ARMCX6 | C10orf62 | ENSP00000444537 | ENSP00000359674 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62. | 0.574 |
ARMCX6 | C1orf189 | ENSP00000444537 | ENSP00000357511 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189. | 0.507 |
ARMCX6 | DRG1 | ENSP00000444537 | ENSP00000329715 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.429 |
ARMCX6 | OR5M3 | ENSP00000444537 | ENSP00000493070 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | Olfactory receptor 5M3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.475 |
ARMCX6 | PASK | ENSP00000444537 | ENSP00000351475 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | PAS domain-containing serine/threonine-protein kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in [...] | 0.411 |
ARMCX6 | TCEAL3 | ENSP00000444537 | ENSP00000361711 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | Transcription elongation factor A protein-like 3; May be involved in transcriptional regulation; Belongs to the TFS-II family. TFA subfamily. | 0.424 |
ARMCX6 | XAGE5 | ENSP00000444537 | ENSP00000342240 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | X antigen family member 5; Belongs to the GAGE family. | 0.433 |
ARMCX6 | ZNF285 | ENSP00000444537 | ENSP00000464788 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | Zinc finger protein 285; May be involved in transcriptional regulation. | 0.447 |
C10orf62 | ARMCX6 | ENSP00000359674 | ENSP00000444537 | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62. | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | 0.574 |
C10orf62 | C1orf189 | ENSP00000359674 | ENSP00000357511 | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62. | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189. | 0.651 |
C10orf62 | DRG1 | ENSP00000359674 | ENSP00000329715 | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62. | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.479 |
C10orf62 | OR5M3 | ENSP00000359674 | ENSP00000493070 | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62. | Olfactory receptor 5M3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.604 |
C10orf62 | PASK | ENSP00000359674 | ENSP00000351475 | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62. | PAS domain-containing serine/threonine-protein kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in [...] | 0.450 |
C10orf62 | XAGE5 | ENSP00000359674 | ENSP00000342240 | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62. | X antigen family member 5; Belongs to the GAGE family. | 0.576 |
C10orf62 | ZNF285 | ENSP00000359674 | ENSP00000464788 | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62. | Zinc finger protein 285; May be involved in transcriptional regulation. | 0.588 |
C1orf189 | ARMCX6 | ENSP00000357511 | ENSP00000444537 | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189. | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family. | 0.507 |
C1orf189 | C10orf62 | ENSP00000357511 | ENSP00000359674 | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189. | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62. | 0.651 |
C1orf189 | DRG1 | ENSP00000357511 | ENSP00000329715 | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189. | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.435 |