C12orf45 protein (human) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C12orf45	CCDC171	ENSP00000447057	ENSP00000370077	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	Coiled-coil domain containing 171.	0.879
C12orf45	CT55	ENSP00000447057	ENSP00000276241	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	Cancer/testis antigen 55.	0.648
C12orf45	DNAJB6	ENSP00000447057	ENSP00000262177	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.	0.811
C12orf45	GAPDH	ENSP00000447057	ENSP00000380070	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...]	0.864
C12orf45	MIPOL1	ENSP00000447057	ENSP00000333539	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	Mirror-image polydactyly 1.	0.680
C12orf45	NOP58	ENSP00000447057	ENSP00000264279	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Belongs to the NOP5/NOP56 family.	0.993
C12orf45	RPAP2	ENSP00000447057	ENSP00000476948	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes; Belongs to the RPAP2 family.	0.978
C12orf45	RUVBL1	ENSP00000447057	ENSP00000318297	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively reg [...]	0.891
C12orf45	RUVBL2	ENSP00000447057	ENSP00000473172	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively re [...]	0.906
C12orf45	SARS1	ENSP00000447057	ENSP00000358939	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). [...]	0.692
CCDC171	C12orf45	ENSP00000370077	ENSP00000447057	Coiled-coil domain containing 171.	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	0.879
CT55	C12orf45	ENSP00000276241	ENSP00000447057	Cancer/testis antigen 55.	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	0.648
DNAJB6	C12orf45	ENSP00000262177	ENSP00000447057	DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	0.811
GAPDH	C12orf45	ENSP00000380070	ENSP00000447057	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...]	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	0.864
MIPOL1	C12orf45	ENSP00000333539	ENSP00000447057	Mirror-image polydactyly 1.	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	0.680
MIPOL1	RPAP2	ENSP00000333539	ENSP00000476948	Mirror-image polydactyly 1.	Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes; Belongs to the RPAP2 family.	0.973
NOP58	C12orf45	ENSP00000264279	ENSP00000447057	Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Belongs to the NOP5/NOP56 family.	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	0.993
NOP58	RUVBL1	ENSP00000264279	ENSP00000318297	Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Belongs to the NOP5/NOP56 family.	RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively reg [...]	0.997
NOP58	RUVBL2	ENSP00000264279	ENSP00000473172	Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Belongs to the NOP5/NOP56 family.	RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively re [...]	0.997
RPAP2	C12orf45	ENSP00000476948	ENSP00000447057	Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes; Belongs to the RPAP2 family.	Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.	0.978