INAFM1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

INAFM1

Putative transmembrane protein INAFM1; InaF motif containing 1. (142 aa)

Predicted Functional Partners:

PRR26

0.570

TMEM59L

0.506

C4orf48

0.495

PRR22

0.492

HCFC1R1

0.491

METTL26

0.462

AGO2

0.457

CAMK2N2

0.456

AFTPH

0.422

FAM160A1

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFTPH	AGO2	ENSP00000238855	ENSP00000220592	Aftiphilin; May play a role in membrane trafficking.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.476
AFTPH	INAFM1	ENSP00000238855	ENSP00000447679	Aftiphilin; May play a role in membrane trafficking.	Putative transmembrane protein INAFM1; InaF motif containing 1.	0.422
AGO2	AFTPH	ENSP00000220592	ENSP00000238855	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Aftiphilin; May play a role in membrane trafficking.	0.476
AGO2	INAFM1	ENSP00000220592	ENSP00000447679	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Putative transmembrane protein INAFM1; InaF motif containing 1.	0.457
C4orf48	CAMK2N2	ENSP00000386807	ENSP00000296238	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	0.559
C4orf48	INAFM1	ENSP00000386807	ENSP00000447679	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Putative transmembrane protein INAFM1; InaF motif containing 1.	0.495
C4orf48	TMEM59L	ENSP00000386807	ENSP00000470879	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	0.605
CAMK2N2	C4orf48	ENSP00000296238	ENSP00000386807	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	0.559
CAMK2N2	INAFM1	ENSP00000296238	ENSP00000447679	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	Putative transmembrane protein INAFM1; InaF motif containing 1.	0.456
CAMK2N2	TMEM59L	ENSP00000296238	ENSP00000470879	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	0.582
FAM160A1	HCFC1R1	ENSP00000413196	ENSP00000248089	Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family.	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	0.489
FAM160A1	INAFM1	ENSP00000413196	ENSP00000447679	Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family.	Putative transmembrane protein INAFM1; InaF motif containing 1.	0.416
FAM160A1	METTL26	ENSP00000413196	ENSP00000440765	Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family.	Methyltransferase like 26.	0.489
HCFC1R1	FAM160A1	ENSP00000248089	ENSP00000413196	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family.	0.489
HCFC1R1	INAFM1	ENSP00000248089	ENSP00000447679	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	Putative transmembrane protein INAFM1; InaF motif containing 1.	0.491
HCFC1R1	METTL26	ENSP00000248089	ENSP00000440765	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	Methyltransferase like 26.	0.584
INAFM1	AFTPH	ENSP00000447679	ENSP00000238855	Putative transmembrane protein INAFM1; InaF motif containing 1.	Aftiphilin; May play a role in membrane trafficking.	0.422
INAFM1	AGO2	ENSP00000447679	ENSP00000220592	Putative transmembrane protein INAFM1; InaF motif containing 1.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.457
INAFM1	C4orf48	ENSP00000447679	ENSP00000386807	Putative transmembrane protein INAFM1; InaF motif containing 1.	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	0.495
INAFM1	CAMK2N2	ENSP00000447679	ENSP00000296238	Putative transmembrane protein INAFM1; InaF motif containing 1.	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	0.456