STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT4Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. (520 aa)    
Predicted Functional Partners:
KRT13
Keratin, type I cytoskeletal 13; Keratin 13.
  
 
0.986
CRNN
Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family.
   
  
 0.704
SPRR3
Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes.
   
 
 0.679
SRR
Serine racemase; Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
    
 
 0.670
MT1A
Metallothionein-1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.
      
 0.666
KRT33A
Keratin, type I cuticular Ha3-I; Keratin 33A; Belongs to the intermediate filament family.
  
 
0.614
KRT15
Keratin, type I cytoskeletal 15; Keratin 15.
  
 
0.593
MT2A
Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.
      
 0.590
IVL
Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family.
   
  
 0.565
KRT78
Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family.
  
 
0.563
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.