Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KRT4Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. (520 aa)    
Predicted Functional Partners:
KRT13
Keratin, type I cytoskeletal 13; Keratin 13.
  
 
0.991
KRT15
Keratin, type I cytoskeletal 15; Keratin 15.
  
 
0.781
KRT33B
Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family.
  
 
0.733
KRT6B
Keratin, type II cytoskeletal 6B; Keratin 6B; Belongs to the intermediate filament family.
  
0.690
KRT38
Keratin, type I cuticular Ha8; Keratin 38; Belongs to the intermediate filament family.
   
 
0.685
KRT3
Keratin, type II cytoskeletal 3; Keratin 3; Belongs to the intermediate filament family.
  
0.683
KRT17
Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...]
   
 
0.674
KRT75
Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
  
0.671
MT1A
Metallothionein-1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.
      
 0.662
KRT16
Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance; Belongs to the intermediate filament family.
   
 
0.662
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.