node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTRC | C12orf75 | ENSP00000359206 | ENSP00000448536 | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradatio [...] | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | 0.557 |
BTRC | ELAVL1 | ENSP00000359206 | ENSP00000385269 | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradatio [...] | ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | 0.758 |
C12orf75 | BTRC | ENSP00000448536 | ENSP00000359206 | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradatio [...] | 0.557 |
C12orf75 | C6orf132 | ENSP00000448536 | ENSP00000341368 | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | Uncharacterized protein C6orf132; Chromosome 6 open reading frame 132. | 0.468 |
C12orf75 | ELAVL1 | ENSP00000448536 | ENSP00000385269 | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | 0.468 |
C12orf75 | INSYN2B | ENSP00000448536 | ENSP00000366582 | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | Protein INSYN2B; Inhibitory synaptic factor family member 2B; Belongs to the INSYN2 family. | 0.407 |
C12orf75 | IRS4 | ENSP00000448536 | ENSP00000361202 | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | Insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin- stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kin [...] | 0.555 |
C12orf75 | IRS4-2 | ENSP00000448536 | ENSP00000457111 | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | Insulin receptor substrate 4. | 0.555 |
C12orf75 | LUZP6 | ENSP00000448536 | ENSP00000468007 | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | Leucine zipper protein 6. | 0.470 |
C12orf75 | UNC119 | ENSP00000448536 | ENSP00000337040 | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Proba [...] | 0.422 |
C6orf132 | C12orf75 | ENSP00000341368 | ENSP00000448536 | Uncharacterized protein C6orf132; Chromosome 6 open reading frame 132. | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | 0.468 |
C6orf132 | INSYN2B | ENSP00000341368 | ENSP00000366582 | Uncharacterized protein C6orf132; Chromosome 6 open reading frame 132. | Protein INSYN2B; Inhibitory synaptic factor family member 2B; Belongs to the INSYN2 family. | 0.596 |
ELAVL1 | BTRC | ENSP00000385269 | ENSP00000359206 | ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradatio [...] | 0.758 |
ELAVL1 | C12orf75 | ENSP00000385269 | ENSP00000448536 | ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | 0.468 |
INSYN2B | C12orf75 | ENSP00000366582 | ENSP00000448536 | Protein INSYN2B; Inhibitory synaptic factor family member 2B; Belongs to the INSYN2 family. | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | 0.407 |
INSYN2B | C6orf132 | ENSP00000366582 | ENSP00000341368 | Protein INSYN2B; Inhibitory synaptic factor family member 2B; Belongs to the INSYN2 family. | Uncharacterized protein C6orf132; Chromosome 6 open reading frame 132. | 0.596 |
IRS4 | C12orf75 | ENSP00000361202 | ENSP00000448536 | Insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin- stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kin [...] | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | 0.555 |
IRS4-2 | C12orf75 | ENSP00000457111 | ENSP00000448536 | Insulin receptor substrate 4. | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | 0.555 |
LUZP6 | C12orf75 | ENSP00000468007 | ENSP00000448536 | Leucine zipper protein 6. | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | 0.470 |
UNC119 | C12orf75 | ENSP00000337040 | ENSP00000448536 | Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Proba [...] | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75. | 0.422 |