METTL7A protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AUP1	METTL7A	ENSP00000366748	ENSP00000448785	Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome; Belongs to the AUP1 family.	Methyltransferase-like protein 7A; Probable methyltransferase.	0.515
METTL17	METTL25	ENSP00000372445	ENSP00000248306	Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family.	Methyltransferase-like protein 25; Putative methyltransferase.	0.470
METTL17	METTL7A	ENSP00000372445	ENSP00000448785	Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family.	Methyltransferase-like protein 7A; Probable methyltransferase.	0.509
METTL17	METTL8	ENSP00000372445	ENSP00000480056	Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family.	mRNA N(3)-methylcytidine methyltransferase METTL8; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs.	0.505
METTL17	PUM1	ENSP00000372445	ENSP00000391723	Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family.	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	0.705
METTL17	PUM2	ENSP00000372445	ENSP00000338173	Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family.	Pumilio homolog 2; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE) (,. Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation- independent repression by promoting accessibility of miRNAs. Acts as a pos [...]	0.705
METTL25	METTL17	ENSP00000248306	ENSP00000372445	Methyltransferase-like protein 25; Putative methyltransferase.	Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family.	0.470
METTL25	METTL7A	ENSP00000248306	ENSP00000448785	Methyltransferase-like protein 25; Putative methyltransferase.	Methyltransferase-like protein 7A; Probable methyltransferase.	0.483
METTL25	METTL8	ENSP00000248306	ENSP00000480056	Methyltransferase-like protein 25; Putative methyltransferase.	mRNA N(3)-methylcytidine methyltransferase METTL8; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs.	0.657
METTL7A	AUP1	ENSP00000448785	ENSP00000366748	Methyltransferase-like protein 7A; Probable methyltransferase.	Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome; Belongs to the AUP1 family.	0.515
METTL7A	METTL17	ENSP00000448785	ENSP00000372445	Methyltransferase-like protein 7A; Probable methyltransferase.	Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family.	0.509
METTL7A	METTL25	ENSP00000448785	ENSP00000248306	Methyltransferase-like protein 7A; Probable methyltransferase.	Methyltransferase-like protein 25; Putative methyltransferase.	0.483
METTL7A	METTL8	ENSP00000448785	ENSP00000480056	Methyltransferase-like protein 7A; Probable methyltransferase.	mRNA N(3)-methylcytidine methyltransferase METTL8; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs.	0.567
METTL7A	PUM1	ENSP00000448785	ENSP00000391723	Methyltransferase-like protein 7A; Probable methyltransferase.	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	0.510
METTL7A	PUM2	ENSP00000448785	ENSP00000338173	Methyltransferase-like protein 7A; Probable methyltransferase.	Pumilio homolog 2; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE) (,. Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation- independent repression by promoting accessibility of miRNAs. Acts as a pos [...]	0.510
METTL7A	SAR1A	ENSP00000448785	ENSP00000362339	Methyltransferase-like protein 7A; Probable methyltransferase.	GTP-binding protein SAR1a; Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).	0.887
METTL7A	SAR1B	ENSP00000448785	ENSP00000385432	Methyltransferase-like protein 7A; Probable methyltransferase.	GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.	0.527
METTL7A	TPT1	ENSP00000448785	ENSP00000477781	Methyltransferase-like protein 7A; Probable methyltransferase.	Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization.	0.476
METTL7A	TSPAN17	ENSP00000448785	ENSP00000309036	Methyltransferase-like protein 7A; Probable methyltransferase.	Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family.	0.733
METTL8	METTL17	ENSP00000480056	ENSP00000372445	mRNA N(3)-methylcytidine methyltransferase METTL8; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs.	Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family.	0.505