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MAN2A2 protein (human) - STRING interaction network
"MAN2A2" - Alpha-mannosidase 2x in Homo sapiens
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MAN2A2Alpha-mannosidase 2x; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway; Mannosidases alpha class 2 (1150 aa)    
Predicted Functional Partners:
MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans; Mannosyl-glycoprotein N-acetylglucosaminyltransferases (445 aa)
     
 
  0.968
MAN1C1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC; Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc (630 aa)
     
 
  0.963
MAN1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (653 aa)
     
 
  0.949
MAN1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (641 aa)
     
 
  0.946
MGAT2
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Catalyzes an essential step in the conversion of oligo- mannose to complex N-glycans; Mannosyl-glycoprotein N-acetylglucosaminyltransferases (447 aa)
     
 
  0.930
CUX1
Homeobox protein cut-like 1; Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5’ and 3’) of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactiv [...] (1516 aa)
     
 
  0.925
GOSR1
Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] (250 aa)
         
  0.913
COG5
Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family (860 aa)
         
  0.911
GOLGA5
Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport (731 aa)
         
  0.907
COG3
Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport; Belongs to the COG3 family (828 aa)
     
 
  0.907
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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