node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM8 | ASB17 | ENSP00000453302 | ENSP00000284142 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.724 |
ADAM8 | ASB2 | ENSP00000453302 | ENSP00000451575 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | Ankyrin repeat and SOCS box protein 2; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [Isoform 2]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA. | 0.555 |
ADAM8 | CP | ENSP00000453302 | ENSP00000264613 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | Ceruloplasmin; Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). | 0.692 |
ADAM8 | EIF3J | ENSP00000453302 | ENSP00000261868 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.497 |
ADAM8 | MMP25 | ENSP00000453302 | ENSP00000337816 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | Matrix metalloproteinase-25; May activate progelatinase A. | 0.466 |
ADAM8 | MMP9 | ENSP00000453302 | ENSP00000361405 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | 67 kDa matrix metalloproteinase-9; May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Belongs to the peptidase M10A family. | 0.560 |
ADAM8 | MRPL13 | ENSP00000453302 | ENSP00000306548 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. | 0.825 |
ADAM8 | PTAFR | ENSP00000453302 | ENSP00000442658 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. | 0.572 |
ADAM8 | SRC | ENSP00000453302 | ENSP00000362680 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.509 |
ADAM8 | TGM6 | ENSP00000453302 | ENSP00000202625 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | Protein-glutamine gamma-glutamyltransferase 6; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.556 |
ASB17 | ADAM8 | ENSP00000284142 | ENSP00000453302 | Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | 0.724 |
ASB17 | ASB2 | ENSP00000284142 | ENSP00000451575 | Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Ankyrin repeat and SOCS box protein 2; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [Isoform 2]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA. | 0.863 |
ASB17 | TGM6 | ENSP00000284142 | ENSP00000202625 | Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Protein-glutamine gamma-glutamyltransferase 6; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.771 |
ASB2 | ADAM8 | ENSP00000451575 | ENSP00000453302 | Ankyrin repeat and SOCS box protein 2; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [Isoform 2]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA. | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | 0.555 |
ASB2 | ASB17 | ENSP00000451575 | ENSP00000284142 | Ankyrin repeat and SOCS box protein 2; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [Isoform 2]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA. | Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.863 |
ASB2 | TGM6 | ENSP00000451575 | ENSP00000202625 | Ankyrin repeat and SOCS box protein 2; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [Isoform 2]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA. | Protein-glutamine gamma-glutamyltransferase 6; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.589 |
CP | ADAM8 | ENSP00000264613 | ENSP00000453302 | Ceruloplasmin; Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | 0.692 |
CP | MRPL13 | ENSP00000264613 | ENSP00000306548 | Ceruloplasmin; Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. | 0.866 |
EIF3J | ADAM8 | ENSP00000261868 | ENSP00000453302 | Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes. | 0.497 |
EIF3J | MRPL13 | ENSP00000261868 | ENSP00000306548 | Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. | 0.785 |