CCDC175 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC175	CLVS2	ENSP00000453940	ENSP00000275162	Coiled-coil domain containing 175.	Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2).	0.613
CCDC175	CNKSR3	ENSP00000453940	ENSP00000475915	Coiled-coil domain containing 175.	Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC).	0.530
CCDC175	FAT2	ENSP00000453940	ENSP00000261800	Coiled-coil domain containing 175.	Protocadherin Fat 2; Involved in the regulation of cell migration. May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).	0.476
CCDC175	JKAMP	ENSP00000453940	ENSP00000450749	Coiled-coil domain containing 175.	JNK1/MAPK8-associated membrane protein; May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum- associated degradation (ERAD) system (By similarity).	0.577
CCDC175	L3HYPDH	ENSP00000453940	ENSP00000247194	Coiled-coil domain containing 175.	Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.	0.508
CCDC175	LYPD6	ENSP00000453940	ENSP00000334463	Coiled-coil domain containing 175.	Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).	0.537
CCDC175	RTN1	ENSP00000453940	ENSP00000267484	Coiled-coil domain containing 175.	Reticulon-1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.	0.569
CCDC175	RTN3	ENSP00000453940	ENSP00000367050	Coiled-coil domain containing 175.	Reticulon-3; May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules.	0.491
CCDC175	SORCS3	ENSP00000453940	ENSP00000358715	Coiled-coil domain containing 175.	Sortilin related VPS10 domain containing receptor 3; Belongs to the VPS10-related sortilin family. SORCS subfamily.	0.474
CCDC175	VWC2	ENSP00000453940	ENSP00000341819	Coiled-coil domain containing 175.	Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).	0.543
CLVS2	CCDC175	ENSP00000275162	ENSP00000453940	Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2).	Coiled-coil domain containing 175.	0.613
CLVS2	CNKSR3	ENSP00000275162	ENSP00000475915	Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2).	Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC).	0.438
CLVS2	VWC2	ENSP00000275162	ENSP00000341819	Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2).	Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).	0.542
CNKSR3	CCDC175	ENSP00000475915	ENSP00000453940	Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC).	Coiled-coil domain containing 175.	0.530
CNKSR3	CLVS2	ENSP00000475915	ENSP00000275162	Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC).	Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2).	0.438
FAT2	CCDC175	ENSP00000261800	ENSP00000453940	Protocadherin Fat 2; Involved in the regulation of cell migration. May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).	Coiled-coil domain containing 175.	0.476
JKAMP	CCDC175	ENSP00000450749	ENSP00000453940	JNK1/MAPK8-associated membrane protein; May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum- associated degradation (ERAD) system (By similarity).	Coiled-coil domain containing 175.	0.577
JKAMP	L3HYPDH	ENSP00000450749	ENSP00000247194	JNK1/MAPK8-associated membrane protein; May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum- associated degradation (ERAD) system (By similarity).	Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.	0.488
JKAMP	RTN1	ENSP00000450749	ENSP00000267484	JNK1/MAPK8-associated membrane protein; May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum- associated degradation (ERAD) system (By similarity).	Reticulon-1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.	0.436
L3HYPDH	CCDC175	ENSP00000247194	ENSP00000453940	Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.	Coiled-coil domain containing 175.	0.508