STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM253Transmembrane protein 253. (217 aa)    
Predicted Functional Partners:
TMEM151B
Transmembrane protein 151B; Belongs to the TMEM151 family.
      
 0.620
TMEM151A
Transmembrane protein 151A.
      
 0.615
WDR49
WD repeat domain 49.
      
 0.583
NOXRED1
NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase.
      
 0.580
TMEM50A
Transmembrane protein 50A; Belongs to the UPF0220 family.
      
 0.545
ARFGEF3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells.
      
 0.541
OR2Z1
Olfactory receptor 2Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.541
TMEM116
Transmembrane protein 116.
      
 0.539
TRMO
tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).
   
  
 0.532
FAM162B
Protein FAM162B; Family with sequence similarity 162 member B.
   
  
 0.489
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.