MKRN2OS protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKMY1	MKRN2OS	ENSP00000385887	ENSP00000455385	Ankyrin repeat and MYND domain containing 1.	MKRN2 opposite strand.	0.441
C11orf53	MKRN2OS	ENSP00000489630	ENSP00000455385	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	MKRN2 opposite strand.	0.417
G2E3	MKRN2OS	ENSP00000206595	ENSP00000455385	G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.	MKRN2 opposite strand.	0.459
MKRN2OS	ANKMY1	ENSP00000455385	ENSP00000385887	MKRN2 opposite strand.	Ankyrin repeat and MYND domain containing 1.	0.441
MKRN2OS	C11orf53	ENSP00000455385	ENSP00000489630	MKRN2 opposite strand.	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	0.417
MKRN2OS	G2E3	ENSP00000455385	ENSP00000206595	MKRN2 opposite strand.	G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.	0.459
MKRN2OS	NACAD	ENSP00000455385	ENSP00000420477	MKRN2 opposite strand.	NAC-alpha domain-containing protein 1; May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity); Belongs to the NAC-alpha family.	0.528
MKRN2OS	NXT2	ENSP00000455385	ENSP00000218004	MKRN2 opposite strand.	NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.	0.457
MKRN2OS	PDCL3	ENSP00000455385	ENSP00000264254	MKRN2 opposite strand.	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis.	0.446
MKRN2OS	TAF5L	ENSP00000455385	ENSP00000258281	MKRN2 opposite strand.	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By [...]	0.442
MKRN2OS	TMEM222	ENSP00000455385	ENSP00000483276	MKRN2 opposite strand.	Transmembrane protein 222.	0.473
NACAD	MKRN2OS	ENSP00000420477	ENSP00000455385	NAC-alpha domain-containing protein 1; May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity); Belongs to the NAC-alpha family.	MKRN2 opposite strand.	0.528
NXT2	MKRN2OS	ENSP00000218004	ENSP00000455385	NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.	MKRN2 opposite strand.	0.457
PDCL3	MKRN2OS	ENSP00000264254	ENSP00000455385	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis.	MKRN2 opposite strand.	0.446
TAF5L	MKRN2OS	ENSP00000258281	ENSP00000455385	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By [...]	MKRN2 opposite strand.	0.442
TMEM222	MKRN2OS	ENSP00000483276	ENSP00000455385	Transmembrane protein 222.	MKRN2 opposite strand.	0.473