SMIM21 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

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same PNG format, but at higher resolution

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C11orf94	KRTAP12-4	ENSP00000401498	ENSP00000375476	Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94.	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	0.481
C11orf94	KRTAP4-4	ENSP00000401498	ENSP00000375076	Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94.	Keratin associated protein 4-4.	0.575
C11orf94	SMIM21	ENSP00000401498	ENSP00000462106	Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94.	Small integral membrane protein 21.	0.484
C11orf94	TAC4	ENSP00000401498	ENSP00000334042	Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94.	Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.	0.584
C3orf22	SMIM17	ENSP00000316644	ENSP00000471126	Uncharacterized protein C3orf22; Chromosome 3 open reading frame 22.	Small integral membrane protein 17.	0.694
C3orf22	SMIM21	ENSP00000316644	ENSP00000462106	Uncharacterized protein C3orf22; Chromosome 3 open reading frame 22.	Small integral membrane protein 21.	0.590
C3orf22	TAC4	ENSP00000316644	ENSP00000334042	Uncharacterized protein C3orf22; Chromosome 3 open reading frame 22.	Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.	0.566
KRTAP12-4	C11orf94	ENSP00000375476	ENSP00000401498	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94.	0.481
KRTAP12-4	KRTAP4-4	ENSP00000375476	ENSP00000375076	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Keratin associated protein 4-4.	0.592
KRTAP12-4	SMIM21	ENSP00000375476	ENSP00000462106	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Small integral membrane protein 21.	0.553
KRTAP12-4	TAC4	ENSP00000375476	ENSP00000334042	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.	0.572
KRTAP4-4	C11orf94	ENSP00000375076	ENSP00000401498	Keratin associated protein 4-4.	Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94.	0.575
KRTAP4-4	KRTAP12-4	ENSP00000375076	ENSP00000375476	Keratin associated protein 4-4.	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	0.592
KRTAP4-4	SMIM21	ENSP00000375076	ENSP00000462106	Keratin associated protein 4-4.	Small integral membrane protein 21.	0.483
KRTAP4-4	TAC4	ENSP00000375076	ENSP00000334042	Keratin associated protein 4-4.	Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.	0.572
SMIM17	C3orf22	ENSP00000471126	ENSP00000316644	Small integral membrane protein 17.	Uncharacterized protein C3orf22; Chromosome 3 open reading frame 22.	0.694
SMIM17	SMIM21	ENSP00000471126	ENSP00000462106	Small integral membrane protein 17.	Small integral membrane protein 21.	0.506
SMIM21	C11orf94	ENSP00000462106	ENSP00000401498	Small integral membrane protein 21.	Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94.	0.484
SMIM21	C3orf22	ENSP00000462106	ENSP00000316644	Small integral membrane protein 21.	Uncharacterized protein C3orf22; Chromosome 3 open reading frame 22.	0.590
SMIM21	KRTAP12-4	ENSP00000462106	ENSP00000375476	Small integral membrane protein 21.	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	0.553