node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARRDC3 | CUEDC1 | ENSP00000265138 | ENSP00000462717 | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family. | CUE domain containing 1. | 0.450 |
ARRDC3 | SMURF2 | ENSP00000265138 | ENSP00000262435 | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family. | E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as [...] | 0.452 |
CDR2L | CUEDC1 | ENSP00000336587 | ENSP00000462717 | Cerebellar degeneration related protein 2 like. | CUE domain containing 1. | 0.524 |
CUEDC1 | ARRDC3 | ENSP00000462717 | ENSP00000265138 | CUE domain containing 1. | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family. | 0.450 |
CUEDC1 | CDR2L | ENSP00000462717 | ENSP00000336587 | CUE domain containing 1. | Cerebellar degeneration related protein 2 like. | 0.524 |
CUEDC1 | CUEDC2 | ENSP00000462717 | ENSP00000358953 | CUE domain containing 1. | CUE domain-containing protein 2; Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. | 0.530 |
CUEDC1 | CUTC | ENSP00000462717 | ENSP00000359507 | CUE domain containing 1. | Copper homeostasis protein cutC homolog; May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. | 0.473 |
CUEDC1 | EIF3D | ENSP00000462717 | ENSP00000216190 | CUE domain containing 1. | Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required f [...] | 0.441 |
CUEDC1 | MRPS23 | ENSP00000462717 | ENSP00000320184 | CUE domain containing 1. | Mitochondrial ribosomal protein S23; Belongs to the mitochondrion-specific ribosomal protein mS23 family. | 0.481 |
CUEDC1 | SMURF2 | ENSP00000462717 | ENSP00000262435 | CUE domain containing 1. | E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as [...] | 0.462 |
CUEDC1 | TMEM92 | ENSP00000462717 | ENSP00000300433 | CUE domain containing 1. | Transmembrane protein 92. | 0.420 |
CUEDC1 | TOM1 | ENSP00000462717 | ENSP00000413697 | CUE domain containing 1. | Target of Myb protein 1; May be involved in intracellular trafficking. Probable association with membranes; Belongs to the TOM1 family. | 0.477 |
CUEDC1 | ZNF114 | ENSP00000462717 | ENSP00000469998 | CUE domain containing 1. | Zinc finger protein 114; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.422 |
CUEDC2 | CUEDC1 | ENSP00000358953 | ENSP00000462717 | CUE domain-containing protein 2; Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. | CUE domain containing 1. | 0.530 |
CUTC | CUEDC1 | ENSP00000359507 | ENSP00000462717 | Copper homeostasis protein cutC homolog; May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. | CUE domain containing 1. | 0.473 |
EIF3D | CUEDC1 | ENSP00000216190 | ENSP00000462717 | Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required f [...] | CUE domain containing 1. | 0.441 |
MRPS23 | CUEDC1 | ENSP00000320184 | ENSP00000462717 | Mitochondrial ribosomal protein S23; Belongs to the mitochondrion-specific ribosomal protein mS23 family. | CUE domain containing 1. | 0.481 |
SMURF2 | ARRDC3 | ENSP00000262435 | ENSP00000265138 | E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as [...] | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family. | 0.452 |
SMURF2 | CUEDC1 | ENSP00000262435 | ENSP00000462717 | E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as [...] | CUE domain containing 1. | 0.462 |
TMEM92 | CUEDC1 | ENSP00000300433 | ENSP00000462717 | Transmembrane protein 92. | CUE domain containing 1. | 0.420 |