node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP1G1 | SPATA33 | ENSP00000377148 | ENSP00000462996 | AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. | Spermatogenesis-associated protein 33; Spermatogenesis associated 33. | 0.451 |
CDK10 | DBNDD1 | ENSP00000338673 | ENSP00000457625 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling ; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Dysbindin domain containing 1. | 0.493 |
CDK10 | DEF8 | ENSP00000338673 | ENSP00000268676 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling ; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | 0.577 |
CDK10 | SPATA33 | ENSP00000338673 | ENSP00000462996 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling ; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Spermatogenesis-associated protein 33; Spermatogenesis associated 33. | 0.539 |
CDK10 | SPIRE2 | ENSP00000338673 | ENSP00000367494 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling ; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nucle [...] | 0.446 |
CENPBD1 | DBNDD1 | ENSP00000393854 | ENSP00000457625 | CENPB DNA-binding domain containing 1. | Dysbindin domain containing 1. | 0.414 |
CENPBD1 | SPATA33 | ENSP00000393854 | ENSP00000462996 | CENPB DNA-binding domain containing 1. | Spermatogenesis-associated protein 33; Spermatogenesis associated 33. | 0.465 |
DBNDD1 | CDK10 | ENSP00000457625 | ENSP00000338673 | Dysbindin domain containing 1. | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling ; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.493 |
DBNDD1 | CENPBD1 | ENSP00000457625 | ENSP00000393854 | Dysbindin domain containing 1. | CENPB DNA-binding domain containing 1. | 0.414 |
DBNDD1 | DEF8 | ENSP00000457625 | ENSP00000268676 | Dysbindin domain containing 1. | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | 0.675 |
DBNDD1 | SPATA33 | ENSP00000457625 | ENSP00000462996 | Dysbindin domain containing 1. | Spermatogenesis-associated protein 33; Spermatogenesis associated 33. | 0.560 |
DBNDD1 | SPIRE2 | ENSP00000457625 | ENSP00000367494 | Dysbindin domain containing 1. | Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nucle [...] | 0.540 |
DEF8 | CDK10 | ENSP00000268676 | ENSP00000338673 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling ; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.577 |
DEF8 | DBNDD1 | ENSP00000268676 | ENSP00000457625 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Dysbindin domain containing 1. | 0.675 |
DEF8 | SPATA33 | ENSP00000268676 | ENSP00000462996 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Spermatogenesis-associated protein 33; Spermatogenesis associated 33. | 0.602 |
DEF8 | SPIRE2 | ENSP00000268676 | ENSP00000367494 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nucle [...] | 0.599 |
KBTBD2 | SPATA33 | ENSP00000302586 | ENSP00000462996 | Kelch repeat and BTB domain containing 2. | Spermatogenesis-associated protein 33; Spermatogenesis associated 33. | 0.447 |
PPP3CC | SPATA33 | ENSP00000380878 | ENSP00000462996 | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32; Belongs to the PPP phosphatase family. PP-2B subfamily. | Spermatogenesis-associated protein 33; Spermatogenesis associated 33. | 0.531 |
SPATA33 | AP1G1 | ENSP00000462996 | ENSP00000377148 | Spermatogenesis-associated protein 33; Spermatogenesis associated 33. | AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. | 0.451 |
SPATA33 | CDK10 | ENSP00000462996 | ENSP00000338673 | Spermatogenesis-associated protein 33; Spermatogenesis associated 33. | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling ; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.539 |