STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM72CProtein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family. (149 aa)    
Predicted Functional Partners:
FAM72B
Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family.
  
  
0.999
ARHGAP11B-2
Rho GTPase activating protein 11B.
   
  
 0.665
FAM72D
Protein FAM72D; Family with sequence similarity 72 member D.
  
  
0.626
ARHGAP11B
Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.
   
  
 0.616
SRGAP2B
SLIT-ROBO Rho GTPase-activating protein 2B; May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.
      
 0.590
ANKRD20A3
Ankyrin repeat domain-containing protein 20A3.
      
 0.518
SRGAP2C
SLIT-ROBO Rho GTPase-activating protein 2C; Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory.
      
 0.517
CBWD6
COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
      
 0.490
CBWD3
COBW domain containing 3.
      
 0.489
TTK
Dual specificity protein kinase TTK; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
   
    0.463
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.