FAM72C protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD20A3	FAM72B	ENSP00000482325	ENSP00000358397	Ankyrin repeat domain-containing protein 20A3.	Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family.	0.465
ANKRD20A3	FAM72C	ENSP00000482325	ENSP00000463032	Ankyrin repeat domain-containing protein 20A3.	Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family.	0.498
ANKRD20A3	FAM72D	ENSP00000482325	ENSP00000383682	Ankyrin repeat domain-containing protein 20A3.	Protein FAM72D; Family with sequence similarity 72 member D.	0.426
ARHGAP11B	ARHGAP11B-2	ENSP00000392760	ENSP00000481934	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.	Rho GTPase activating protein 11B.	0.859
ARHGAP11B	DLGAP5	ENSP00000392760	ENSP00000247191	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.	Disks large-associated protein 5; Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.	0.620
ARHGAP11B	FAM72B	ENSP00000392760	ENSP00000358397	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.	Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family.	0.577
ARHGAP11B	FAM72C	ENSP00000392760	ENSP00000463032	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.	Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family.	0.600
ARHGAP11B	FAM72D	ENSP00000392760	ENSP00000383682	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.	Protein FAM72D; Family with sequence similarity 72 member D.	0.540
ARHGAP11B	KIF2C	ENSP00000392760	ENSP00000361298	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.	Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end- on conversion of the chromosome-microtubule attachment ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.	0.572
ARHGAP11B	SRGAP2B	ENSP00000392760	ENSP00000493121	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.	SLIT-ROBO Rho GTPase-activating protein 2B; May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.	0.535
ARHGAP11B	TTK	ENSP00000392760	ENSP00000358813	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.	Dual specificity protein kinase TTK; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.	0.686
ARHGAP11B-2	ARHGAP11B	ENSP00000481934	ENSP00000392760	Rho GTPase activating protein 11B.	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity.	0.859
ARHGAP11B-2	DLGAP5	ENSP00000481934	ENSP00000247191	Rho GTPase activating protein 11B.	Disks large-associated protein 5; Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.	0.620
ARHGAP11B-2	FAM72B	ENSP00000481934	ENSP00000358397	Rho GTPase activating protein 11B.	Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family.	0.612
ARHGAP11B-2	FAM72C	ENSP00000481934	ENSP00000463032	Rho GTPase activating protein 11B.	Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family.	0.636
ARHGAP11B-2	FAM72D	ENSP00000481934	ENSP00000383682	Rho GTPase activating protein 11B.	Protein FAM72D; Family with sequence similarity 72 member D.	0.585
ARHGAP11B-2	KIF2C	ENSP00000481934	ENSP00000361298	Rho GTPase activating protein 11B.	Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end- on conversion of the chromosome-microtubule attachment ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.	0.572
ARHGAP11B-2	SRGAP2B	ENSP00000481934	ENSP00000493121	Rho GTPase activating protein 11B.	SLIT-ROBO Rho GTPase-activating protein 2B; May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.	0.549
ARHGAP11B-2	TTK	ENSP00000481934	ENSP00000358813	Rho GTPase activating protein 11B.	Dual specificity protein kinase TTK; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.	0.686
ARHGEF35	FAM72B	ENSP00000367355	ENSP00000358397	Rho guanine nucleotide exchange factor 35.	Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family.	0.444