Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM30 | NBPF10 | ENSP00000358407 | ENSP00000463957 | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation. | Neuroblastoma breakpoint family member 10; NBPF member 10. | 0.411 |
| ANKRD20A4 | NBPF10 | ENSP00000349891 | ENSP00000463957 | Ankyrin repeat domain-containing protein 20A4. | Neuroblastoma breakpoint family member 10; NBPF member 10. | 0.454 |
| MDM2 | NBPF10 | ENSP00000258149 | ENSP00000463957 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] | Neuroblastoma breakpoint family member 10; NBPF member 10. | 0.405 |
| MDM2 | TP53 | ENSP00000258149 | ENSP00000269305 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.999 |
| NBPF10 | ADAM30 | ENSP00000463957 | ENSP00000358407 | Neuroblastoma breakpoint family member 10; NBPF member 10. | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation. | 0.411 |
| NBPF10 | ANKRD20A4 | ENSP00000463957 | ENSP00000349891 | Neuroblastoma breakpoint family member 10; NBPF member 10. | Ankyrin repeat domain-containing protein 20A4. | 0.454 |
| NBPF10 | MDM2 | ENSP00000463957 | ENSP00000258149 | Neuroblastoma breakpoint family member 10; NBPF member 10. | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] | 0.405 |
| NBPF10 | NBPF19-2 | ENSP00000463957 | ENSP00000478752 | Neuroblastoma breakpoint family member 10; NBPF member 10. | Neuroblastoma breakpoint family member 19; Belongs to the NBPF family. | 0.423 |
| NBPF10 | NBPF26 | ENSP00000463957 | ENSP00000481542 | Neuroblastoma breakpoint family member 10; NBPF member 10. | Neuroblastoma breakpoint family member 26; NBPF member 26. | 0.456 |
| NBPF10 | NOTCH2NLA | ENSP00000463957 | ENSP00000354929 | Neuroblastoma breakpoint family member 10; NBPF member 10. | Notch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | 0.431 |
| NBPF10 | NOTCH2NLB | ENSP00000463957 | ENSP00000472124 | Neuroblastoma breakpoint family member 10; NBPF member 10. | Notch homolog 2 N-terminal-like protein B; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | 0.543 |
| NBPF10 | TP53 | ENSP00000463957 | ENSP00000269305 | Neuroblastoma breakpoint family member 10; NBPF member 10. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.508 |
| NBPF19-2 | NBPF10 | ENSP00000478752 | ENSP00000463957 | Neuroblastoma breakpoint family member 19; Belongs to the NBPF family. | Neuroblastoma breakpoint family member 10; NBPF member 10. | 0.423 |
| NBPF19-2 | NOTCH2NLA | ENSP00000478752 | ENSP00000354929 | Neuroblastoma breakpoint family member 19; Belongs to the NBPF family. | Notch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | 0.667 |
| NBPF19-2 | NOTCH2NLB | ENSP00000478752 | ENSP00000472124 | Neuroblastoma breakpoint family member 19; Belongs to the NBPF family. | Notch homolog 2 N-terminal-like protein B; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | 0.507 |
| NBPF26 | NBPF10 | ENSP00000481542 | ENSP00000463957 | Neuroblastoma breakpoint family member 26; NBPF member 26. | Neuroblastoma breakpoint family member 10; NBPF member 10. | 0.456 |
| NOTCH2NLA | NBPF10 | ENSP00000354929 | ENSP00000463957 | Notch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | Neuroblastoma breakpoint family member 10; NBPF member 10. | 0.431 |
| NOTCH2NLA | NBPF19-2 | ENSP00000354929 | ENSP00000478752 | Notch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | Neuroblastoma breakpoint family member 19; Belongs to the NBPF family. | 0.667 |
| NOTCH2NLA | NOTCH2NLB | ENSP00000354929 | ENSP00000472124 | Notch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | Notch homolog 2 N-terminal-like protein B; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | 0.410 |
| NOTCH2NLB | NBPF10 | ENSP00000472124 | ENSP00000463957 | Notch homolog 2 N-terminal-like protein B; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | Neuroblastoma breakpoint family member 10; NBPF member 10. | 0.543 |
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