| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD29 | GREB1L | ENSP00000468354 | ENSP00000464162 | Ankyrin repeat domain 29. | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.478 |
| ANKRD29 | TMEM241 | ENSP00000468354 | ENSP00000372720 | Ankyrin repeat domain 29. | Transmembrane protein 241. | 0.580 |
| CEP192 | GREB1L | ENSP00000427550 | ENSP00000464162 | Centrosomal protein of 192 kDa; Required for mitotic centrosome maturation and bipolar spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. Centrosome- specific activating scaffold for AURKA and PLK1. | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.456 |
| CEP192 | VIRMA | ENSP00000427550 | ENSP00000297591 | Centrosomal protein of 192 kDa; Required for mitotic centrosome maturation and bipolar spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. Centrosome- specific activating scaffold for AURKA and PLK1. | Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...] | 0.492 |
| CLP1 | GREB1L | ENSP00000434995 | ENSP00000464162 | Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this pho [...] | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.810 |
| CLP1 | TSEN2 | ENSP00000434995 | ENSP00000284995 | Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this pho [...] | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | 0.999 |
| GREB1L | ANKRD29 | ENSP00000464162 | ENSP00000468354 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Ankyrin repeat domain 29. | 0.478 |
| GREB1L | CEP192 | ENSP00000464162 | ENSP00000427550 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Centrosomal protein of 192 kDa; Required for mitotic centrosome maturation and bipolar spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. Centrosome- specific activating scaffold for AURKA and PLK1. | 0.456 |
| GREB1L | CLP1 | ENSP00000464162 | ENSP00000434995 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this pho [...] | 0.810 |
| GREB1L | LYPD4 | ENSP00000464162 | ENSP00000476510 | GREB1-like protein; Plays a major role in early metanephros and genital development. | LY6/PLAUR domain containing 4. | 0.495 |
| GREB1L | NEK4 | ENSP00000464162 | ENSP00000233027 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.456 |
| GREB1L | ROCK1 | ENSP00000464162 | ENSP00000382697 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as [...] | 0.532 |
| GREB1L | TMEM241 | ENSP00000464162 | ENSP00000372720 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Transmembrane protein 241. | 0.478 |
| GREB1L | TSEN2 | ENSP00000464162 | ENSP00000284995 | GREB1-like protein; Plays a major role in early metanephros and genital development. | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | 0.813 |
| GREB1L | VGLL3 | ENSP00000464162 | ENSP00000381436 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Transcription cofactor vestigial-like protein 3; May act as a specific coactivator for the mammalian TEFs. | 0.538 |
| GREB1L | VIRMA | ENSP00000464162 | ENSP00000297591 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...] | 0.457 |
| LYPD4 | GREB1L | ENSP00000476510 | ENSP00000464162 | LY6/PLAUR domain containing 4. | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.495 |
| NEK4 | GREB1L | ENSP00000233027 | ENSP00000464162 | Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.456 |
| NEK4 | VIRMA | ENSP00000233027 | ENSP00000297591 | Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...] | 0.475 |
| ROCK1 | GREB1L | ENSP00000382697 | ENSP00000464162 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as [...] | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.532 |
