| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAAP1 | GREB1L | ENSP00000369431 | ENSP00000464162 | Caspase activity and apoptosis inhibitor 1; Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.459 |
| CLP1 | GREB1L | ENSP00000434995 | ENSP00000464162 | Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this pho [...] | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.538 |
| CLP1 | TSEN2 | ENSP00000434995 | ENSP00000284995 | Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this pho [...] | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | 0.990 |
| DZIP1L | GREB1L | ENSP00000332148 | ENSP00000464162 | Zinc finger protein DZIP1L; Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane ; Belongs to the DZIP C2H2-type zinc-finger protein family. | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.414 |
| GREB1L | CAAP1 | ENSP00000464162 | ENSP00000369431 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Caspase activity and apoptosis inhibitor 1; Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. | 0.459 |
| GREB1L | CLP1 | ENSP00000464162 | ENSP00000434995 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this pho [...] | 0.538 |
| GREB1L | DZIP1L | ENSP00000464162 | ENSP00000332148 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Zinc finger protein DZIP1L; Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane ; Belongs to the DZIP C2H2-type zinc-finger protein family. | 0.414 |
| GREB1L | ROCK1 | ENSP00000464162 | ENSP00000382697 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as [...] | 0.492 |
| GREB1L | TMEM241 | ENSP00000464162 | ENSP00000372720 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Transmembrane protein 241. | 0.464 |
| GREB1L | TSEN2 | ENSP00000464162 | ENSP00000284995 | GREB1-like protein; Plays a major role in early metanephros and genital development. | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | 0.521 |
| GREB1L | TULP4 | ENSP00000464162 | ENSP00000356064 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the TUB family. | 0.464 |
| GREB1L | VGLL3 | ENSP00000464162 | ENSP00000381436 | GREB1-like protein; Plays a major role in early metanephros and genital development. | Transcription cofactor vestigial-like protein 3; May act as a specific coactivator for the mammalian TEFs. | 0.504 |
| ROCK1 | GREB1L | ENSP00000382697 | ENSP00000464162 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as [...] | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.492 |
| TMEM241 | GREB1L | ENSP00000372720 | ENSP00000464162 | Transmembrane protein 241. | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.464 |
| TSEN2 | CLP1 | ENSP00000284995 | ENSP00000434995 | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this pho [...] | 0.990 |
| TSEN2 | GREB1L | ENSP00000284995 | ENSP00000464162 | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.521 |
| TULP4 | GREB1L | ENSP00000356064 | ENSP00000464162 | Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the TUB family. | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.464 |
| TULP4 | VGLL3 | ENSP00000356064 | ENSP00000381436 | Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the TUB family. | Transcription cofactor vestigial-like protein 3; May act as a specific coactivator for the mammalian TEFs. | 0.422 |
| VGLL3 | GREB1L | ENSP00000381436 | ENSP00000464162 | Transcription cofactor vestigial-like protein 3; May act as a specific coactivator for the mammalian TEFs. | GREB1-like protein; Plays a major role in early metanephros and genital development. | 0.504 |
| VGLL3 | TULP4 | ENSP00000381436 | ENSP00000356064 | Transcription cofactor vestigial-like protein 3; May act as a specific coactivator for the mammalian TEFs. | Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the TUB family. | 0.422 |
STRING v12.5 is now available!
