node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBX | CC2D1A | ENSP00000319974 | ENSP00000313601 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase. | Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When c [...] | 0.418 |
BBX | MEF2D | ENSP00000319974 | ENSP00000271555 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase. | Myocyte-specific enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). | 0.406 |
BBX | ZNF286A | ENSP00000319974 | ENSP00000464218 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase. | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.475 |
CC2D1A | BBX | ENSP00000313601 | ENSP00000319974 | Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When c [...] | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase. | 0.418 |
CC2D1A | MEF2D | ENSP00000313601 | ENSP00000271555 | Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When c [...] | Myocyte-specific enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). | 0.566 |
CC2D1A | ZNF286A | ENSP00000313601 | ENSP00000464218 | Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When c [...] | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.588 |
DIPK1C | ZNF286A | ENSP00000344331 | ENSP00000464218 | Divergent protein kinase domain 1C. | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.429 |
FOXG1 | ZNF286A | ENSP00000339004 | ENSP00000464218 | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.417 |
MEF2D | BBX | ENSP00000271555 | ENSP00000319974 | Myocyte-specific enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase. | 0.406 |
MEF2D | CC2D1A | ENSP00000271555 | ENSP00000313601 | Myocyte-specific enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). | Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When c [...] | 0.566 |
MEF2D | ZNF286A | ENSP00000271555 | ENSP00000464218 | Myocyte-specific enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.428 |
TRIM28 | ZNF286A | ENSP00000253024 | ENSP00000464218 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.518 |
ZNF121 | ZNF286A | ENSP00000468643 | ENSP00000464218 | Zinc finger protein 121; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.464 |
ZNF286A | BBX | ENSP00000464218 | ENSP00000319974 | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase. | 0.475 |
ZNF286A | CC2D1A | ENSP00000464218 | ENSP00000313601 | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When c [...] | 0.588 |
ZNF286A | DIPK1C | ENSP00000464218 | ENSP00000344331 | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Divergent protein kinase domain 1C. | 0.429 |
ZNF286A | FOXG1 | ENSP00000464218 | ENSP00000339004 | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. | 0.417 |
ZNF286A | MEF2D | ENSP00000464218 | ENSP00000271555 | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Myocyte-specific enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). | 0.428 |
ZNF286A | TRIM28 | ENSP00000464218 | ENSP00000253024 | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.518 |
ZNF286A | ZNF121 | ENSP00000464218 | ENSP00000468643 | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 121; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.464 |