L7N2F9_HUMAN protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L7N2F9_HUMAN	NAPB	ENSP00000464383	ENSP00000482826	V-SNARE coiled-coil homology domain-containing protein.	Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	0.614
L7N2F9_HUMAN	STX16	ENSP00000464383	ENSP00000360183	V-SNARE coiled-coil homology domain-containing protein.	Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	0.504
L7N2F9_HUMAN	STX1A	ENSP00000464383	ENSP00000222812	V-SNARE coiled-coil homology domain-containing protein.	Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...]	0.906
L7N2F9_HUMAN	SYNPR	ENSP00000464383	ENSP00000418994	V-SNARE coiled-coil homology domain-containing protein.	Synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity); Belongs to the synaptophysin/synaptobrevin family.	0.537
L7N2F9_HUMAN	SYP	ENSP00000464383	ENSP00000263233	V-SNARE coiled-coil homology domain-containing protein.	Synaptophysin; Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity); Belongs to the synaptophysin/synaptobrevin family.	0.885
L7N2F9_HUMAN	SYT1	ENSP00000464383	ENSP00000261205	V-SNARE coiled-coil homology domain-containing protein.	Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...]	0.776
L7N2F9_HUMAN	SYT2	ENSP00000464383	ENSP00000356237	V-SNARE coiled-coil homology domain-containing protein.	Synaptotagmin-2; Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes. Belongs to the synaptotagmin family.	0.779
L7N2F9_HUMAN	VAMP2	ENSP00000464383	ENSP00000418572	V-SNARE coiled-coil homology domain-containing protein.	Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Belongs to the synaptobrevin family.	0.809
L7N2F9_HUMAN	VAMP3	ENSP00000464383	ENSP00000054666	V-SNARE coiled-coil homology domain-containing protein.	Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	0.808
L7N2F9_HUMAN	VAMP4	ENSP00000464383	ENSP00000236192	V-SNARE coiled-coil homology domain-containing protein.	Vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.	0.677
NAPB	L7N2F9_HUMAN	ENSP00000482826	ENSP00000464383	Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	V-SNARE coiled-coil homology domain-containing protein.	0.614
NAPB	STX16	ENSP00000482826	ENSP00000360183	Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	0.949
NAPB	STX1A	ENSP00000482826	ENSP00000222812	Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...]	0.774
NAPB	VAMP2	ENSP00000482826	ENSP00000418572	Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Belongs to the synaptobrevin family.	0.758
NAPB	VAMP3	ENSP00000482826	ENSP00000054666	Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	0.750
NAPB	VAMP4	ENSP00000482826	ENSP00000236192	Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	Vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.	0.951
STX16	L7N2F9_HUMAN	ENSP00000360183	ENSP00000464383	Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	V-SNARE coiled-coil homology domain-containing protein.	0.504
STX16	NAPB	ENSP00000360183	ENSP00000482826	Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	0.949
STX16	STX1A	ENSP00000360183	ENSP00000222812	Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...]	0.958
STX16	VAMP2	ENSP00000360183	ENSP00000418572	Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Belongs to the synaptobrevin family.	0.722