STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF285Zinc finger protein 285; May be involved in transcriptional regulation. (597 aa)    
Predicted Functional Partners:
C10orf62
Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62.
    
 
 0.588
DENND6A
Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; Belongs to the DENND6 family.
      
 0.545
C1orf189
Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189.
      
 0.544
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]
   
 0.522
OR5M3
Olfactory receptor 5M3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.506
CAPN15
Calpain-15; Calpain 15; Belongs to the peptidase C2 family.
   
 
 0.484
XAGE5
X antigen family member 5; Belongs to the GAGE family.
      
 0.447
TIGD5
Tigger transposable element derived 5.
      
 0.447
ARMCX6
Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family.
      
 0.447
MAMLD1
Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family.
   
 
 0.425
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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